Eng Guan Chua

TL;DR: Preliminary data to determine, in vitro, if fucoidans can inhibit the growth of H. pylori and its ability to adhere to gastric epithelial cells (AGS), and the basis for further studies on the clinical use of sulphated polysaccharides as complementary therapeutic agents are provided.

TL;DR: It is demonstrated that urease expression is not only required for establishing initial colonization but also for maintaining chronic infection, and the tet-system described here opens up opportunities to studying genes involved in the chronic stage of H. pylori infection to gain insight into bacterial mechanisms promoting immune escape and life-long infection.

TL;DR: The genome of the human gastric pathogen Helicobacter pylori is sequenced using a combination of PacBio Single Molecule, Real-Time (SMRT) and Illumina next generation sequencing platforms, and methylated sequence motifs corresponding to one Type I and 16 Type II restriction-modification (R-M) systems are revealed.

TL;DR: The MBL IP/IPI E-test was shown to achieve 100% sensitivity as well as specificity for the IRPA in this study, and is proposed to be a viable alternative phenotypic assay to detect MBL production in IRpa in the population in circumstances where PCR detection is not a feasible option.

TL;DR: It is suggested that local microbiome dysbiosis may contribute to functional changes at the cancer sites in CRC and supported the quest for understanding the mechanisms of carcinogenesis.