Fanny Thirriot

TL;DR: Helicobacter pylori eradication rates with standard triple therapy are declining worldwide, and new treatment combinations for antibiotic resistant H.pylori strains are required, especially for patients with penicillin allergy.

TL;DR: The genome of the human gastric pathogen Helicobacter pylori is sequenced using a combination of PacBio Single Molecule, Real-Time (SMRT) and Illumina next generation sequencing platforms, and methylated sequence motifs corresponding to one Type I and 16 Type II restriction-modification (R-M) systems are revealed.

TL;DR: This work sequenced and analysed strains J99 and 26695 using the benchtop-sequencing machines Ion Torrent PGM and the Illumina MiSeq Nextera and Nextera XT methodologies and found the cagPAI failed to assemble onto a single contig in all technologies but was more accurate using the Nextera.

TL;DR: Genomic analyses showed that H. heilmannii harbors some outer membrane proteins that are not present in H. ailurogastricus, but their role in the colonization process is so far unknown, which supports their re-classification as a novel species for which the name H. ailments nov (of a cat’s stomach) is proposed.

TL;DR: In conclusion, the optimal first-line H. pylori eradication therapy has yet to be discovered and levofloxacin-containing sequential therapy can be used as an alternative strategy.