Update of the Stroke Therapy Academic Industry Roundtable Preclinical Recommendations
Marc Fisher,Marc Fisher,Giora Z. Feuerstein,David W. Howells,Patricia D. Hurn,Thomas A. Kent,Sean I Savitz,Eng H. Lo +7 more
Reads0
Chats0
TLDR
The updated STAIR preclinical recommendations reinforce the previous suggestions that reproducibly defining dose response and time windows with both histological and functional outcomes in multiple animal species with appropriate physiological monitoring is appropriate.Abstract:
The initial Stroke Therapy Academic Industry Roundtable (STAIR) recommendations published in 1999 were intended to improve the quality of preclinical studies of purported acute stroke therapies Although recognized as reasonable, they have not been closely followed nor rigorously validated Substantial advances have occurred regarding the appropriate quality and breadth of preclinical testing for candidate acute stroke therapies for better clinical translation The updated STAIR preclinical recommendations reinforce the previous suggestions that reproducibly defining dose response and time windows with both histological and functional outcomes in multiple animal species with appropriate physiological monitoring is appropriate The updated STAIR recommendations include: the fundamentals of good scientific inquiry should be followed by eliminating randomization and assessment bias, a priori defining inclusion/exclusion criteria, performing appropriate power and sample size calculations, and disclosing potential conflicts of interest After initial evaluations in young, healthy male animals, further studies should be performed in females, aged animals, and animals with comorbid conditions such as hypertension, diabetes, and hypercholesterolemia Another consideration is the use of clinically relevant biomarkers in animal studies Although the recommendations cannot be validated until effective therapies based on them emerge from clinical trials, it is hoped that adherence to them might enhance the chances for successread more
Citations
More filters
Journal ArticleDOI
The methodological quality assessment tools for preclinical and clinical studies, systematic review and meta‐analysis, and clinical practice guideline: a systematic review
Xian-Tao Zeng,Yonggang Zhang,Joey S.W. Kwong,Chao Zhang,Sheng Li,Feng Sun,Yuming Niu,Liang Du +7 more
TL;DR: To systematically review the methodological assessment tools for pre‐clinical and clinical studies, systematic review and meta‐analysis, and clinical practice guideline.
Journal ArticleDOI
A call for transparent reporting to optimize the predictive value of preclinical research
Story C. Landis,Susan G. Amara,Khusru Asadullah,Christopher P. Austin,Robi Blumenstein,Eileen W. Bradley,Ronald G. Crystal,Robert B. Darnell,Robert J. Ferrante,Howard Fillit,Robert Finkelstein,Marc Fisher,Howard E. Gendelman,Robert M. Golub,John L. Goudreau,Robert A. Gross,Amelie K. Gubitz,Sharon E. Hesterlee,David W. Howells,John R. Huguenard,Katrina Kelner,Walter J. Koroshetz,Dimitri Krainc,Stanley E. Lazic,Michael Levine,Malcolm R. Macleod,John M. McCall,Richard T. Moxley,Kalyani Narasimhan,Linda Noble,Steve Perrin,John D. Porter,Oswald Steward,Ellis F. Unger,Ursula Utz,Shai D. Silberberg +35 more
TL;DR: The main workshop recommendation is that at a minimum studies should report on sample-size estimation, whether and how animals were randomized, whether investigators were blind to the treatment, and the handling of data.
Journal ArticleDOI
Traumatic spinal cord injury
Christopher S. Ahuja,Jefferson R. Wilson,Satoshi Nori,Mark R. N. Kotter,Claudia Druschel,Armin Curt,Michael G. Fehlings,Michael G. Fehlings +7 more
TL;DR: Several animal models and complementary behavioural tests of SCI have been developed to mimic this pathological process and form the basis for the development of preclinical and translational neuroprotective and neuroregenerative strategies.
Journal ArticleDOI
A catalogue of reporting guidelines for health research.
TL;DR: The EQUATOR Network as mentioned in this paper is an international initiative that aims to enhance the reliability and value of the published health research literature by providing resources, education and training to facilitate good research reporting and assists in the development, dissemination and implementation of robust reporting guidelines.
Journal ArticleDOI
Reducing excessive GABA-mediated tonic inhibition promotes functional recovery after stroke
TL;DR: This work shows that after a stroke in mice, tonic neuronal inhibition is increased in the peri-infarct zone, and identifies new pharmacological targets that provide the rationale for a novel strategy to promote recovery after stroke and possibly other brain injuries.
References
More filters
Journal ArticleDOI
Tissue plasminogen activator for acute ischemic stroke. The National Institute of Neurological Disorders and Stroke rt-PA Stroke Study Group.
James C. Grotta,M Kothari,K.M.A. Welch,Joseph P. Broderick,Barbara C. Tilley,Thomas G. Brott,Marler,Patrick D. Lyden,Paul M. O'Byrne +8 more
Journal ArticleDOI
The Revised CONSORT Statement for Reporting Randomized Trials: Explanation and Elaboration
Douglas G. Altman,Kenneth F. Schulz,David Moher,Matthias Egger,Frank Davidoff,Diana Elbourne,Peter C Gøtzsche,Tom Lang +7 more
TL;DR: The Consort Statement as mentioned in this paper is a group of scientists and editors developed to improve the quality of reporting of randomized, controlled trials (RCTs) by providing guidance to authors about how to improve their reporting of their trials.
Journal ArticleDOI
Improving the quality of reporting of randomized controlled trials. The CONSORT statement.
Colin B. Begg,Mildred K. Cho,Susan Eastwood,Richard Horton,David Moher,Ingram Olkin,Roy M. Pitkin,Drummond Rennie,Kenneth F. Schulz,David L. Simel,Donna F. Stroup +10 more
TL;DR: For RCTs to ultimately benefit patients, the published report should be of the highest possible standard and should provide the reader with the ability to make informed judgments regarding the internal and external validity of the trial.
Journal ArticleDOI
Improving the quality of reporting of randomized controlled trials. The CONSORT statement
Colin B. Begg,Mildred K. Cho,Susan Eastwood,Richard Horton,David Moher,Ingram Olkin,Roy M. Pitkin,Drummond Rennie,Kenneth F. Schulz,David L. Simel,Donna F. Stroup +10 more
TL;DR: For RCTs to ultimately benefit patients, the published report should be of the highest possible standard and accurate and complete reporting is needed.
Journal ArticleDOI
1,026 Experimental treatments in acute stroke
Victoria E O'Collins,Malcolm R. Macleod,Geoffrey A. Donnan,Laura L. Horky,Bart van der Worp,David W. Howells +5 more
TL;DR: This work endeavored to contrast experimental efficacy and scope of testing of drugs used clinically and those tested only experimentally.