E
Enza Lacivita
Researcher at University of Bari
Publications - 111
Citations - 2731
Enza Lacivita is an academic researcher from University of Bari. The author has contributed to research in topics: Receptor & Agonist. The author has an hindex of 30, co-authored 100 publications receiving 2327 citations. Previous affiliations of Enza Lacivita include Mario Negri Institute for Pharmacological Research.
Papers
More filters
Journal ArticleDOI
Design, synthesis, and binding affinities of potential positron emission tomography (PET) ligands for visualization of brain dopamine D3 receptors.
Marcello Leopoldo,Enza Lacivita,Paola De Giorgio,Nicola Antonio Colabufo,Mauro Niso,Francesco Berardi,Roberto Perrone +6 more
TL;DR: The goal to identify potential PET radioligands with subnanomolar affinities for D(3) receptor was not achieved, but the proposed strategy could be a starting point for future developments.
Journal ArticleDOI
4-[ω-[4-Arylpiperazin-1-yl]alkoxy]phenyl)imidazo[1,2-a]pyridine Derivatives: Fluorescent High-Affinity Dopamine D3 Receptor Ligands as Potential Probes for Receptor Visualization
Marcello Leopoldo,Enza Lacivita,Elena Passafiume,Marialessandra Contino,Nicola Antonio Colabufo,Francesco Berardi,Roberto Perrone +6 more
TL;DR: Sixteen long-chain arylpiperazines bearing the fluorescent moiety 2-phenylimidazo[1,2-a]pyridine were synthesized as fluorescent dopamine D3 receptors ligands, and the most pote...
Journal ArticleDOI
The 5-HT7 receptor triggers cerebellar long-term synaptic depression via PKC-MAPK
Pellegrino Lippiello,Eriola Hoxha,Luisa Speranza,Floriana Volpicelli,Angela Ferraro,Marcello Leopoldo,Enza Lacivita,Carla Perrone-Capano,Filippo Tempia,Maria Concetta Miniaci +9 more
TL;DR: It is shown for the first time that 5-HT7R exerts a fine regulation of cerebellar bidirectional synaptic plasticity that might be involved in cognitive processes and neuropsychiatric disorders involving the cerebellum.
Journal ArticleDOI
Stimulation of the brain serotonin receptor 7 rescues mitochondrial dysfunction in female mice from two models of Rett syndrome.
Daniela Valenti,Lidia de Bari,Daniele Vigli,Enza Lacivita,Marcello Leopoldo,Giovanni Laviola,Rosa Anna Vacca,Bianca De Filippis +7 more
TL;DR: Results provide the first evidence that RTT brain mitochondrial dysfunction can be rescued targeting the brain 5-HT7R and add compelling preclinical evidence of the potential therapeutic value of LP-211 as a pharmacological approach for this devastating neurodevelopmental disorder.
Journal ArticleDOI
Investigations on the 1-(2-Biphenyl)piperazine Motif: Identification of New Potent and Selective Ligands for the Serotonin7 (5-HT7) Receptor with Agonist or Antagonist Action in Vitro or ex Vivo
Enza Lacivita,Daniela Patarnello,Nikolas Stroth,Antonia Caroli,Mauro Niso,Marialessandra Contino,Paola De Giorgio,Pantaleo Di Pilato,Nicola Antonio Colabufo,Francesco Berardi,Roberto Perrone,Per Svenningsson,Peter B. Hedlund,Marcello Leopoldo +13 more
TL;DR: 1-[2-(4-Methoxyphenyl)phenyl]piperazine (9a) showed 5-HT(7) agonist properties in a guinea pig ileum assay but blocked5-HT-mediated cAMP accumulation in 5- HT(7)-expressing HeLa cells.