P
Pantaleo Di Pilato
Researcher at University of Bari
Publications - 7
Citations - 178
Pantaleo Di Pilato is an academic researcher from University of Bari. The author has contributed to research in topics: Receptor & 5-HT receptor. The author has an hindex of 5, co-authored 7 publications receiving 154 citations.
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Journal ArticleDOI
Selective agonists for serotonin 7 (5-HT7) receptor and their applications in preclinical models: an overview.
Pantaleo Di Pilato,Mauro Niso,Walter Adriani,Emilia Romano,Domenica Travaglini,Francesco Berardi,Nicola Antonio Colabufo,Roberto Perrone,Giovanni Laviola,Enza Lacivita,Marcello Leopoldo +10 more
TL;DR: The data indicate that 5-HT7 receptor agonists can have neuroprotective effects against N-methyl-d-aspartate-induced toxicity, modulate neuronal plasticity in rats, enhance morphine-induced antinociception and alleviate hyperalgesia consecutive to nerve lesion in neuropathic animals.
Journal ArticleDOI
Investigations on the 1-(2-Biphenyl)piperazine Motif: Identification of New Potent and Selective Ligands for the Serotonin7 (5-HT7) Receptor with Agonist or Antagonist Action in Vitro or ex Vivo
Enza Lacivita,Daniela Patarnello,Nikolas Stroth,Antonia Caroli,Mauro Niso,Marialessandra Contino,Paola De Giorgio,Pantaleo Di Pilato,Nicola Antonio Colabufo,Francesco Berardi,Roberto Perrone,Per Svenningsson,Peter B. Hedlund,Marcello Leopoldo +13 more
TL;DR: 1-[2-(4-Methoxyphenyl)phenyl]piperazine (9a) showed 5-HT(7) agonist properties in a guinea pig ileum assay but blocked5-HT-mediated cAMP accumulation in 5- HT(7)-expressing HeLa cells.
Journal ArticleDOI
The therapeutic potential of 5-HT1A receptors: a patent review
Enza Lacivita,Pantaleo Di Pilato,Paola De Giorgio,Nicola Antonio Colabufo,Francesco Berardi,Roberto Perrone,Marcello Leopoldo +6 more
TL;DR: The discovery that stimulation of 5- HT1A receptor can promote neurogenesis will likely renew the interest for selective 5-HT1A receptors agonists as therapeutics to replace neural populations damaged by disease or injury.
Journal ArticleDOI
Synthesis, radiolabeling and in vivo evaluation of [11C](R)-1-[4-[2-(4-methoxyphenyl)phenyl]piperazin-1-yl]-3-(2-pyrazinyloxy)-2-propanol, a potential PET radioligand for the 5-HT7 receptor
Hanne D. Hansen,Enza Lacivita,Pantaleo Di Pilato,Matthias M. Herth,Szabolcs Lehel,Anders Ettrup,Valdemar L. Andersen,Agnete Dyssegaard,Paola De Giorgio,Roberto Perrone,Francesco Berardi,Nicola Antonio Colabufo,Mauro Niso,Gitte M. Knudsen,Marcello Leopoldo +14 more
TL;DR: Pretreatment with the 5-HT7 receptor selective antagonist SB-269970 resulted in limited decrease in the binding of [(11)C](R)-16, suggesting that this radioligand is not optimal for imaging the brain 5-ht7 receptor in vivo but it may serve as a lead compound for the design of novel 5- HT7 receptor PET radiolIGands.
Journal ArticleDOI
Design, synthesis, radiolabeling and in vivo evaluation of potential positron emission tomography (PET) radioligands for brain imaging of the 5-HT7 receptor
Enza Lacivita,Mauro Niso,Hanne D. Hansen,Pantaleo Di Pilato,Matthias M. Herth,Szabolcs Lehel,Anders Ettrup,Lisa Montenegro,Roberto Perrone,Francesco Berardi,Nicola Antonio Colabufo,Marcello Leopoldo,Gitte M. Knudsen +12 more
TL;DR: The design, synthesis, and pharmacological evaluation of a set of compounds structurally related to the high affinity serotonin 5-HT7 receptor agonist N-(4-cyanophenylmethylmethyl)-4-(2-diphenyl)-1-piperazinehexanamide (6, LP-211) are described.