E
Era Taoufik
Researcher at Pasteur Institute
Publications - 25
Citations - 979
Era Taoufik is an academic researcher from Pasteur Institute. The author has contributed to research in topics: Neuroprotection & Induced pluripotent stem cell. The author has an hindex of 14, co-authored 23 publications receiving 837 citations.
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Journal ArticleDOI
Ischemic Neuronal Damage
Era Taoufik,Lesley Probert +1 more
TL;DR: Evidence will be presented on how ischemic injury occurs, what death mechanisms are activated and how these can be manipulated to induce neuroprotection.
Journal ArticleDOI
Defective synaptic connectivity and axonal neuropathology in a human iPSC-based model of familial Parkinson’s disease
Georgia Kouroupi,Era Taoufik,Ioannis S. Vlachos,Konstantinos Tsioras,Nasia Antoniou,Florentia Papastefanaki,Dafni Chroni-Tzartou,Dafni Chroni-Tzartou,Wolfgang Wrasidlo,Delphine Bohl,Dimitris Stellas,Panagiotis K. Politis,Kostas Vekrellis,Dimitra Papadimitriou,Leonidas Stefanis,Leonidas Stefanis,Piotr Bregestovski,Artemis G. Hatzigeorgiou,Eliezer Masliah,Rebecca Matsas +19 more
TL;DR: iPSC-derived mutant neurons displayed novel disease-relevant phenotypes, including protein aggregation, compromised neuritic outgrowth, and contorted or fragmented axons with swollen varicosities containing αSyn and Tau, raising intriguing implications for potentially converging disease mechanisms.
Journal ArticleDOI
TNF receptor I sensitizes neurons to erythropoietin- and VEGF-mediated neuroprotection after ischemic and excitotoxic injury.
Era Taoufik,Edwige Petit,Didier Divoux,Vivian Tseveleki,Manuela Mengozzi,Michael L. Roberts,Samuel Valable,Pietro Ghezzi,John Quackenbush,Michael Brines,Anthony Cerami,Lesley Probert +11 more
TL;DR: The results identify cross-talk between tissue protective cytokines, specifically that TNFRI is necessary for constitutive and GD-induced expression of EPOR and VEGF and for EPO-mediated neuroprotection.
Journal ArticleDOI
Synaptic dysfunction in neurodegenerative and neurodevelopmental diseases: an overview of induced pluripotent stem-cell-based disease models.
TL;DR: This review discusses synaptic dysfunction in prototype neurodevelopmental and neurodegenerative diseases, emphasizing overlapping features of synaptopathy that have been suggested by studies using induced pluripotent stem-cell-based systems.
Journal ArticleDOI
In vivo investigation of tolerance and antitumor activity of cisplatin-loaded PLGA-mPEG nanoparticles.
George Mattheolabakis,Era Taoufik,Sylva Haralambous,Michael L. Roberts,Konstantinos Avgoustakis +4 more
TL;DR: The cisplatin-loaded PLGA-mPEG/cisplatin nanoparticles appeared to be effective at delaying tumor growth in HT 29 tumor-bearing SCID mice and exhibited higher survival rate compared to the free cisPlatin group.