Eran Meshorer

TL;DR: The data suggest that changes in chromatin dynamics underlie the transitions in cellular plasticity and that higher chromatin mobility is at the nuclear foundations of totipotency.

TL;DR: Using epigenetic drugs and mutant embryonic stem cells lacking various chromatin proteins, it is found that histone acetylation, G9a-mediated histone H3 lysine 9 (H3K9) methylation and lamin A expression, all affect chromatin protein dynamics, and indicates that the genome's epigenetic state modulates chromatin plasticity and differentiation potential of embryonicstem cells.

TL;DR: Plasticity in pluripotency and embryonic stem cell self-renewal seems to be supported more by different mechanisms maintaining an open chromatin state and less by regulating the location of genomic regions.

TL;DR: Together, these data delineate the global epigenetic state of iPSCs in conjunction with their pluripotent state, and demonstrate that heterochromatin precedes euchromatin in reorganization during reprogramming.

TL;DR: Unexpectedly one of the 5′ exons encodes an extended N terminus in-frame with the known AChE sequence, extending the increased complexity to the protein level, and may lead to stress-dependent combinatorial complexity of ACHE mRNA transcripts and their protein products.