E
Erasmus Schneider
Researcher at New York State Department of Health
Publications - 62
Citations - 4256
Erasmus Schneider is an academic researcher from New York State Department of Health. The author has contributed to research in topics: Multiple drug resistance & Apoptosis. The author has an hindex of 32, co-authored 61 publications receiving 4081 citations. Previous affiliations of Erasmus Schneider include National Institutes of Health & Johns Hopkins University.
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Journal ArticleDOI
Atypical multidrug resistance: breast cancer resistance protein messenger RNA expression in mitoxantrone-selected cell lines.
Douglas D. Ross,Weidong Yang,Lynne V. Abruzzo,William S. Dalton,Erasmus Schneider,Hermann Lage,Manfred Dietel,Lee Greenberger,Susan P.C. Cole,L. Austin Doyle +9 more
TL;DR: In this article, the prevalence of BCRP overexpression in cell lines selected for growth in the presence of mitoxantrone was found to be a major cellular defense mechanism elicited in response to exposure to this drug.
Journal Article
Multidrug resistance-associated protein gene overexpression and reduced drug sensitivity of topoisomerase II in a human breast carcinoma MCF7 cell line selected for etoposide resistance.
Erasmus Schneider,Julie K. Horton,Julie K. Horton,Chih Hsin Yang,Masayuki Nakagawa,Kenneth H. Cowan +5 more
TL;DR: The results suggest that resistance to epipodophyllotoxins in MCF7/VP cells is multifactorial, involving a reduction in intracellular drug concentration, possibly as a consequence of MRP overexpression, and an altered DNA topoisomerase II drug sensitivity.
Journal Article
Overexpression of wild-type breast cancer resistance protein mediates methotrexate resistance.
TL;DR: A novel role for BCRP as a mediator of MTX resistance is demonstrated and further evidence for the importance of amino acid 482 in substrate specificity is provided.
Journal Article
Wild-type breast cancer resistance protein (BCRP/ABCG2) is a methotrexate polyglutamate transporter.
Erin L Volk,Erasmus Schneider +1 more
TL;DR: Evidence is provided for BCRP as a MTX-transporter using an in vitro membrane vesicle system and a possible mechanism by which it confers resistance is revealed.
Journal ArticleDOI
Increased expression of the multidrug resistance-associated protein gene in relapsed acute leukemia.
Erasmus Schneider,Kenneth H. Cowan,Helaine Bader,Sara L. Toomey,Gretchen N. Schwartz,Judith E. Karp,Philip J. Burke,Scott H. Kaufmann +7 more
TL;DR: Analysis of paired samples from 13 acute myelogenous leukemia (AML) and four acute lymphocytic leukemia (ALL) patients showed that MRP expression was increased at the time of relapse in greater than 80% of patients, raising the possibility that increased MRPexpression might contribute to leukemic relapse.