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Eric M. Bachelder
Researcher at University of North Carolina at Chapel Hill
Publications - 101
Citations - 3791
Eric M. Bachelder is an academic researcher from University of North Carolina at Chapel Hill. The author has contributed to research in topics: Medicine & Adjuvant. The author has an hindex of 31, co-authored 81 publications receiving 2976 citations. Previous affiliations of Eric M. Bachelder include University of Nebraska–Lincoln & Ohio State University.
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Acetal-Derivatized Dextran: An Acid-Responsive Biodegradable Material for Therapeutic Applications
TL;DR: Owing to its ease of preparation, processability, pH-sensitivity, and biocompatibility, this type of modified dextran should find use in numerous drug delivery applications.
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Acetalated dextran is a chemically and biologically tunable material for particulate immunotherapy
TL;DR: In this article, a biocompatible material that can be formed into microparticles with degradation rates that are tunable over 2 orders of magnitude depending on the degree and type of acetal modification is presented.
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Fully Acid-Degradable Biocompatible Polyacetal Microparticles for Drug Delivery
Sergey E. Paramonov,Eric M. Bachelder,Tristan T. Beaudette,Stephany M. Standley,Cameron C. Lee,Jesse Dashe,Jean M. J. Fréchet +6 more
TL;DR: The ease of preparation of the polymers coupled with the ability to tune their hydrophobicity and the high acid sensitivity of the microparticles identify this new class of materials as promising candidates for the delivery of bioactive materials.
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A nanoparticle-incorporated STING activator enhances antitumor immunity in PD-L1–insensitive models of triple-negative breast cancer
Ning Cheng,Rebekah Watkins-Schulz,Robert D. Junkins,Clément N. David,Brandon M. Johnson,Stephanie A. Montgomery,Kevin J. Peine,David B. Darr,Hong Yuan,Karen P. McKinnon,Qi Liu,Lei Miao,Leaf Huang,Eric M. Bachelder,Kristy M. Ainslie,Jenny P.-Y. Ting +15 more
TL;DR: It is shown that liposomal nanoparticle-delivered cGAMP (cGAMP-NP) activates STING more effectively than soluble cGamp, and suggests that a minimal system comprised of cGamping-NP alone is sufficient to modulate the tumor microenvironment to effectively control PD-L1-insensitive TNBC.
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'Educated' dendritic cells act as messengers from memory to naive T helper cells.
TL;DR: Using chimeric mice generated by aggregation of two genotypically different embryos, it is found that the conversion of a naive T cell occurs only if it can interact with the same antigen-presenting cell, although not necessarily theSame antigen, as the effector T cell.