J
Jenny P.-Y. Ting
Researcher at University of North Carolina at Chapel Hill
Publications - 20
Citations - 2973
Jenny P.-Y. Ting is an academic researcher from University of North Carolina at Chapel Hill. The author has contributed to research in topics: Inflammasome & Immune system. The author has an hindex of 10, co-authored 20 publications receiving 1501 citations. Previous affiliations of Jenny P.-Y. Ting include St. Jude Children's Research Hospital.
Papers
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Journal ArticleDOI
The NLRP3 inflammasome: molecular activation and regulation to therapeutics
TL;DR: The NLRP3 inflammasome mediates pro-inflammatory responses and pyroptotic cell death and how it is being targeted to treat inflammatory diseases is described.
Journal ArticleDOI
NLR members NLRC4 and NLRP3 mediate sterile inflammasome activation in microglia and astrocytes.
Leslie Freeman,Haitao Guo,Clément N. David,W. June Brickey,Sushmita Jha,Sushmita Jha,Jenny P.-Y. Ting +6 more
TL;DR: It is revealed that lysophosphatidylcholine (LPC), a molecule associated with neurodegeneration and demyelination, elicits NLRP3 and NLRC4 inflammasome activation in microglia and astrocytes, which are central players in neuroinflammation.
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A nanoparticle-incorporated STING activator enhances antitumor immunity in PD-L1–insensitive models of triple-negative breast cancer
Ning Cheng,Rebekah Watkins-Schulz,Robert D. Junkins,Clément N. David,Brandon M. Johnson,Stephanie A. Montgomery,Kevin J. Peine,David B. Darr,Hong Yuan,Karen P. McKinnon,Qi Liu,Lei Miao,Leaf Huang,Eric M. Bachelder,Kristy M. Ainslie,Jenny P.-Y. Ting +15 more
TL;DR: It is shown that liposomal nanoparticle-delivered cGAMP (cGAMP-NP) activates STING more effectively than soluble cGamp, and suggests that a minimal system comprised of cGamping-NP alone is sufficient to modulate the tumor microenvironment to effectively control PD-L1-insensitive TNBC.
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A noncanonical function of cGAMP in inflammasome priming and activation.
Karen V. Swanson,Robert D. Junkins,Cathryn J. Kurkjian,Elizabeth Holley-Guthrie,Avani A. Pendse,Rachid El Morabiti,Alex Petrucelli,Glen N. Barber,Chris A. Benedict,Jenny P.-Y. Ting +9 more
TL;DR: It is shown that cGAMP has a noncanonical function in inflammasome activation in human and mouse cells and is needed to control infection by a DNA virus.
Journal ArticleDOI
Differential induction of type I interferon responses in myeloid dendritic cells by mosquito and mammalian-cell-derived alphaviruses.
Reed S. Shabman,Thomas E. Morrison,Chris B. Moore,Laura K. White,Mehul S. Suthar,Linda Hueston,Nestor E. Rulli,Brett A. Lidbury,Jenny P.-Y. Ting,Suresh Mahalingam,Mark T. Heise +10 more
TL;DR: Alphaviruses were used to determine whether viruses grown in mosquito cells differed from mammalian-cell-derived viruses in their ability to induce type I interferon (IFN) responses in infected primary dendritic cells, and results suggest that the viruses initially delivered by the mosquito vector differ from those generated in subsequent rounds of replication in the host.