Eric Perouzel

TL;DR: This work reports the long-awaited identification of Dectin-1 and Siglec-5 as the M cell co-receptors that mediate the reverse transcytosis of secretory IgA molecules to mount a gut immune response.

TL;DR: Co-injection of encapsulated Nod-ligands with PLA particles carrying Gag p24 HIV-1 antigen allowed a 100 fold increase in antibody responses in comparison to Alum.

TL;DR: New compounds inducing stronger immune responses than the currently available Mincle ligands that represent new powerful adjuvant molecules are synthesized and found to induce strong Th1 and Th17 immune responses in vivo in immunization experiments in mice and conferred protection in a murine model of Mycobacteria tuberculosis infection.

TL;DR: LMD particles can be formulated reproducibly, they are amenable to long-term storage at −80°C and are stable to aggregation at a plasmid DNA concentration up to 5 mg/ml, which make LMD an important new non-viral vector platform system from which to derive tailor-made non-Viral delivery systems by a process of systematic modular upgrading.

TL;DR: LD systems prepared from DC‐Chol/DOPE cationic liposomes and pDNA(Cy3) behave similarly to LMD systems, which suggests that mu peptide is unable to influence trafficking events in this current LMD formulation, in spite of its strong NLS capacity.