D
David B. Finkelstein
Researcher at St. Jude Children's Research Hospital
Publications - 22
Citations - 1914
David B. Finkelstein is an academic researcher from St. Jude Children's Research Hospital. The author has contributed to research in topics: Cellular differentiation & Nucleic acid. The author has an hindex of 13, co-authored 21 publications receiving 1725 citations. Previous affiliations of David B. Finkelstein include The Research Institute at Nationwide Children's Hospital & University of Kentucky.
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Journal ArticleDOI
Subtypes of medulloblastoma have distinct developmental origins
Paul Gibson,Yiai Tong,Giles W. Robinson,Margaret C. Thompson,D. Spencer Currle,Christopher G Eden,Tanya A. Kranenburg,Twala L. Hogg,Helen Poppleton,Julie Martin,David B. Finkelstein,Stanley Pounds,Aaron Weiss,Zoltan Patay,Matthew A. Scoggins,Robert J. Ogg,Yanxin Pei,Zeng-Jie Yang,Sonja N. Brun,Youngsoo Lee,Frederique Zindy,Janet C. Lindsey,Makoto Mark Taketo,Frederick A. Boop,Robert A. Sanford,Amar Gajjar,Steven C. Clifford,Martine F. Roussel,Peter J. McKinnon,David H. Gutmann,David W. Ellison,Robert J. Wechsler-Reya,Richard J. Gilbertson +32 more
TL;DR: Evidence is provided that a discrete subtype of medulloblastoma that contains activating mutations in the WNT pathway effector CTNNB1 (hereafter, WNT subtype) arises outside the cerebellum from cells of the dorsal brainstem, the first evidence, to the authors' knowledge, that subtypes of medULLoblastomas have distinct cellular origins.
Journal ArticleDOI
Large-Scale Sequence Analysis of Avian Influenza Isolates
John C. Obenauer,Jackie Denson,Perdeep K. Mehta,Xiaoping Su,Suraj Mukatira,David B. Finkelstein,Xiequn Xu,Jinhua Wang,Jing Ma,Yiping Fan,Karen M. Rakestraw,Robert G. Webster,Robert G. Webster,Erich Hoffmann,Scott Krauss,Jie Zheng,Ziwei Zhang,Clayton W. Naeve,Clayton W. Naeve +18 more
TL;DR: A preliminary analysis of the first large-scale sequencing of AIVs, including 2196 AIV genes and 169 complete genomes, is reported here to identify new gene alleles, persistent genotypes, compensatory mutations, and a potential virulence determinant.
Journal ArticleDOI
Persistent Host Markers in Pandemic and H5N1 Influenza Viruses
David B. Finkelstein,Suraj Mukatira,Perdeep K. Mehta,John C. Obenauer,Xiaoping Su,Robert G. Webster,Clayton W. Naeve,Clayton W. Naeve +7 more
TL;DR: It is found that a subset of these persistent host markers exist in all human pandemic influenza virus sequences from 1918, 1957, and 1968, while others are acquired as the virus becomes a seasonal influenza virus.
Journal ArticleDOI
Distinct Epigenetic Signatures Delineate Transcriptional Programs during Virus-Specific CD8+ T Cell Differentiation
Brendan E. Russ,Moshe Olshanksy,Heather S. Smallwood,Jasmine Li,Alice E. Denton,Julia E. Prier,Angus T. Stock,Hayley A Croom,Jolie G. Cullen,Michelle L.T. Nguyen,Stephanie Rowe,Matthew R. Olson,David B. Finkelstein,Anne Kelso,Paul G. Thomas,Terry P. Speed,Sudha Rao,Stephen J. Turner +17 more
TL;DR: Assessment of histone H3 methylation dynamics within naive, effector, and memory virus-specific T cells isolated directly ex vivo after influenza A virus infection shows coordinate transcriptional regulation of CTL genes with related functions is achieved via distinct epigenetic mechanisms.
Journal ArticleDOI
MYCN induces neuroblastoma in primary neural crest cells
Rachelle R. Olsen,Joel H. Otero,Jesus Garcia-Lopez,Kirby Wallace,David B. Finkelstein,Jerold E. Rehg,Zhirong Yin,Yong Dong Wang,Kevin W. Freeman +8 more
TL;DR: This work reports the first successful transformation of wild-type NCCs into NBL by enforced expression of N-Myc, to generate phenotypically and molecularly accurate tumors that closely model human MYCN-amplified NBL.