E
Erich Klem
Researcher at University of North Carolina at Chapel Hill
Publications - 14
Citations - 1311
Erich Klem is an academic researcher from University of North Carolina at Chapel Hill. The author has contributed to research in topics: Sputum & Lung microbiome. The author has an hindex of 10, co-authored 14 publications receiving 1190 citations.
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Journal ArticleDOI
The adult cystic fibrosis airway microbiota is stable over time and infection type, and highly resilient to antibiotic treatment of exacerbations.
Anthony A. Fodor,Erich Klem,Deirdre Gilpin,J. Stuart Elborn,Richard C. Boucher,Michael M. Tunney,Matthew C. Wolfgang +6 more
TL;DR: The results indicate that the adult CF lung microbiome is largely stable through periods of exacerbation and antibiotic treatment and that short-term compositional changes in the airway microbiota do not account for CF pulmonary exacerbations.
Journal ArticleDOI
Lung Microbiota and Bacterial Abundance in Patients with Bronchiectasis when Clinically Stable and during Exacerbation
Michael M. Tunney,Gisli G. Einarsson,Lan Wei,Maire Drain,Erich Klem,Christopher Cardwell,Madeleine Ennis,Richard C. Boucher,Matthew C. Wolfgang,J. Stuart Elborn +9 more
TL;DR: A complex microbiota is present in the lungs of patients with bronchiectasis and remains stable through treatment of exacerbations, suggesting that changes in microbiota composition do not account for exacerbations.
Journal ArticleDOI
Use of culture and molecular analysis to determine the effect of antibiotic treatment on microbial community diversity and abundance during exacerbation in patients with cystic fibrosis
Michael M. Tunney,Erich Klem,Anthony A. Fodor,Deirdre Gilpin,Thomas Fintan Moriarty,Stephanie McGrath,Marianne S. Muhlebach,Richard C. Boucher,Christopher Cardwell,Gerd Doering,Joseph Elborn,Matthew C. Wolfgang +11 more
TL;DR: Antibiotic treatment targeted against aerobes had a minimal effect on abundance of anaerobes and community composition, with both culture and molecular detection methods required for comprehensive characterisation of the microbial community in the CF lung.
Journal ArticleDOI
The Pseudomonas aeruginosa Chp chemosensory system regulates intracellular cAMP levels by modulating adenylate cyclase activity.
TL;DR: A novel function for a chemotaxis‐like system in controlling cAMP production is defined and a regulatory link between the Chp system, TFP and other cAMP‐dependent virulence systems is established.
Journal ArticleDOI
In Vitro and In Vivo Characterization of the Pseudomonas aeruginosa Cyclic AMP (cAMP) Phosphodiesterase CpdA, Required for cAMP Homeostasis and Virulence Factor Regulation
Erin L. Fuchs,Evan D. Brutinel,Erich Klem,Anthony R. Fehr,Timothy L. Yahr,Matthew C. Wolfgang +5 more
TL;DR: It is demonstrated that the cAMP-dependent transcription factor Vfr directly regulates cpdA expression in response to intracellular cAMP accumulation, thus providing a feedback mechanism for controlling cAMP levels and fine-tuning virulence factor expression.