E
Erik D. Herzog
Researcher at Washington University in St. Louis
Publications - 150
Citations - 10882
Erik D. Herzog is an academic researcher from Washington University in St. Louis. The author has contributed to research in topics: Circadian rhythm & Suprachiasmatic nucleus. The author has an hindex of 48, co-authored 141 publications receiving 9499 citations. Previous affiliations of Erik D. Herzog include Syracuse University & Arizona State University.
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Journal ArticleDOI
Vasoactive intestinal polypeptide mediates circadian rhythmicity and synchrony in mammalian clock neurons
TL;DR: It is concluded that VIP coordinates daily rhythms in the SCN and behavior by synchronizing a small population of pacemaking neurons and maintaining rhythmicity in a larger subset of neurons.
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A circadian clock in macrophages controls inflammatory immune responses.
Maren Keller,Jeannine Mazuch,Ute Abraham,Gina D. Eom,Erik D. Herzog,Hans-Dieter Volk,Achim Kramer,Bert Maier +7 more
TL;DR: It is shown that spleen, lymph nodes, and peritoneal macrophages of mice contain intrinsic circadian clockworks that operate autonomously even ex vivo, including many important regulators for pathogen recognition and cytokine secretion.
Journal ArticleDOI
Circadian rhythms in isolated brain regions.
Michikazu Abe,Erik D. Herzog,Erik D. Herzog,Shin Yamazaki,Marty Straume,Hajime Tei,Yoshiyuki Sakaki,Michael Menaker,Gene D. Block +8 more
TL;DR: The results indicate that the brain contains multiple, damped circadian oscillators outside the SCN, and the phasing of these oscillators to one another may play a critical role in coordinating brain activity and its adjustment to changes in the light cycle.
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Sirt1 Extends Life Span and Delays Aging in Mice through the Regulation of Nk2 Homeobox 1 in the DMH and LH
Akiko Satoh,Cynthia S. Brace,Nick Rensing,Paul F. Cliften,David F. Wozniak,Erik D. Herzog,Kelvin A. Yamada,Shin-ichiro Imai +7 more
TL;DR: It is demonstrated that brain-specific Sirt1-overexpressing (BRASTO) transgenic mice show significant life span extension in both males and females, and aged BRASTO mice exhibit phenotypes consistent with a delay in aging.
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Clock controls circadian period in isolated suprachiasmatic nucleus neurons.
TL;DR: The results suggest that the Clock gene is required for circadian rhythmicity in individual SCN cells and that a mechanism within the SCN synchronizes neurons and restricts the range of expressed circadian periods.