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Gene D. Block
Researcher at University of California, Los Angeles
Publications - 121
Citations - 9577
Gene D. Block is an academic researcher from University of California, Los Angeles. The author has contributed to research in topics: Circadian rhythm & Suprachiasmatic nucleus. The author has an hindex of 44, co-authored 118 publications receiving 8939 citations. Previous affiliations of Gene D. Block include University of Virginia & University of Pittsburgh.
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Journal ArticleDOI
Resetting Central and Peripheral Circadian Oscillators in Transgenic Rats
Shin Yamazaki,Rika Numano,Michikazu Abe,Akiko Hida,Ri Ichi Takahashi,Masatsugu Ueda,Gene D. Block,Yoshiyuki Sakaki,Michael Menaker,Hajime Tei +9 more
TL;DR: It is hypothesize that a self-sustained circadian pacemaker in the SCN entrains circadian oscillators in the periphery to maintain adaptive phase control, which is temporarily lost following large, abrupt shifts in the environmental light cycle.
Journal ArticleDOI
Circadian rhythms in isolated brain regions.
Michikazu Abe,Erik D. Herzog,Erik D. Herzog,Shin Yamazaki,Marty Straume,Hajime Tei,Yoshiyuki Sakaki,Michael Menaker,Gene D. Block +8 more
TL;DR: The results indicate that the brain contains multiple, damped circadian oscillators outside the SCN, and the phasing of these oscillators to one another may play a critical role in coordinating brain activity and its adjustment to changes in the light cycle.
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Population expansion, clonal growth, and specific differentiation patterns in primary cultures of hepatocytes induced by HGF/SF, EGF and TGF alpha in a chemically defined (HGM) medium.
Gene D. Block,Joseph Locker,William C. Bowen,Bryon E. Petersen,Sikandar L. Katyal,Stephen C. Strom,Thomas Riley,Tamara A. Howard,George K. Michalopoulos +8 more
TL;DR: The hypothesis that mature hepatocytes can function as or be a source of bipotential facultative hepatic stem cells (hepatoblasts) is supported and evidence for the growth factor and matrix signals that govern these complex phenotypic transitions of facultative stem cells are provided.
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Clock controls circadian period in isolated suprachiasmatic nucleus neurons.
TL;DR: The results suggest that the Clock gene is required for circadian rhythmicity in individual SCN cells and that a mechanism within the SCN synchronizes neurons and restricts the range of expressed circadian periods.
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Chronic jet-lag increases mortality in aged mice
TL;DR: Document S1.