E
Erik Spek
Researcher at Cell Signaling Technology
Publications - 11
Citations - 1331
Erik Spek is an academic researcher from Cell Signaling Technology. The author has contributed to research in topics: Tyrosine phosphorylation & Phosphorylation. The author has an hindex of 6, co-authored 11 publications receiving 1285 citations.
Papers
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Journal ArticleDOI
Immunoaffinity profiling of tyrosine phosphorylation in cancer cells
John Rush,Albrecht Moritz,Kimberly Lee,Ailan Guo,Valerie Goss,Erik Spek,Hui Zhang,Hui Zhang,Hui Zhang,Xiang-ming Zha,Xiang-ming Zha,Xiang-ming Zha,Roberto D. Polakiewicz,Michael J. Comb +13 more
TL;DR: Applying this approach to several cell systems, including cancer cell lines, shows it can be used to identify activated protein kinases and their phosphorylated substrates without prior knowledge of the signaling networks that are activated, a first step in profiling normal and oncogenic signaling networks.
Journal ArticleDOI
A common phosphotyrosine signature for the Bcr-Abl kinase
Valerie Goss,Kimberly Lee,Albrecht Moritz,Julie Nardone,Erik Spek,Joan MacNeill,John Rush,Michael J. Comb,Roberto D. Polakiewicz +8 more
TL;DR: A phosphoproteomic study of the Bcr-Abl fusion kinase highlights novel disease markers and potential drug-responsive biomarkers and adds novel insight into the oncogenic signals driven by the BCr-ABL kinase.
Patent
Tyrosine phosphorylation sites
Peter Hornbeck,Ailan Guo,Klarisa Rikova,Albrecht Moritz,Erik Spek,Anthony Possemato,Charles Farnsworth,Francesco Boccalatte,Jian Yu,Jeffrey Mitchell,John Rush,Valerie Goss,Ting-Lei Gu,Yu Li,Matthew P. Stokes +14 more
TL;DR: In this article, the authors disclosed 318 novel phosphorylation sites identified in carcinoma, peptides (including AQUA peptides) comprising a phosphoriclation site of the invention, and antibodies specifically binding to a novel phosphoric activation site.
Patent
Reagents for the detection of protein phosphorylation in carcinoma signaling pathways
Roberto D. Polakiewicz,Kimberly Lee,Charles Farnsworth,Ailan Guo,Klarisa Rikova,Yu Li,Albrecht Moritz,Erik Spek +7 more
TL;DR: In this article, the authors reveal nearly 474 novel phosphorylation sites identified in signal transduction proteins and pathways underlying human carcinoma, and provide a method of using the reagents for such purpose.
Patent
Tyrosine phosphorylation sites and antibodies specific for them
Peter Hornbeck,Ailan Guo,Ting-Lei Gu,Klarisa Rikova,Albrecht Moritz,Charles Farnsworth,Matthew P. Stokes,Yu Jian,Erik Spek,Yu Li,Valerie Goss,Francesco Boccalatte +11 more
TL;DR: In this article, the authors disclosed 482 novel phosphorylation sites identified in carcinoma and/or leukemia, peptides (including AQUA peptides) comprising a phosphorylated site of the invention, antibodies specifically binding to a novel phosphoriclation site of this site, and diagnostic and therapeutic uses of the above.