Jeffrey Mitchell

TL;DR: By focusing on activated cell circuitry, the approach outlined here provides insight into cancer biology not available at the chromosomal and transcriptional levels and can be applied broadly across all human cancers.

TL;DR: Comparing non-small-cell lung cancer cell lines driven by EGFR-activating mutations and genomic amplifications using a global proteomic analysis of phospho-tyrosine signaling identifies an extensive receptor tyrosine kinase signaling network established in cells expressing mutated and activated EGFR or expressing amplified c-Met.

TL;DR: In this article, the authors disclosed 318 novel phosphorylation sites identified in carcinoma, peptides (including AQUA peptides) comprising a phosphoriclation site of the invention, and antibodies specifically binding to a novel phosphoric activation site.

TL;DR: In this paper, 332 novel acetylation sites identified in various cancers, peptides (including AQUA peptides) comprising a single-acetylation site of the invention, antibodies specifically bind to a novel Acetylation Site of the invented peptide, and diagnostic and therapeutic uses of the above.

TL;DR: In this paper, the authors reveal 426 novel acetylation sites identified in signal transduction proteins and pathways underlying human protein acetylations signaling pathways, and provide a method of using the reagents for such purpose.