P
Peter Hornbeck
Researcher at Cell Signaling Technology
Publications - 73
Citations - 7669
Peter Hornbeck is an academic researcher from Cell Signaling Technology. The author has contributed to research in topics: Phosphorylation & Antibody. The author has an hindex of 25, co-authored 71 publications receiving 6395 citations. Previous affiliations of Peter Hornbeck include University of California, San Francisco & National Institutes of Health.
Papers
More filters
Journal ArticleDOI
PhosphoSitePlus, 2014: mutations, PTMs and recalibrations
TL;DR: The ‘PTMVar’ dataset, an intersect of missense mutations and PTMs from PSP, identifies over 25 000 PTMVars (PTMs Impacted by Variants) that can rewire signaling pathways.
Journal ArticleDOI
PhosphoSitePlus: a comprehensive resource for investigating the structure and function of experimentally determined post-translational modifications in man and mouse
Peter Hornbeck,Jon M. Kornhauser,Sasha Tkachev,Bin Zhang,Elzbieta Skrzypek,Beth L. Murray,Vaughan Latham,Michael Sullivan +7 more
TL;DR: PhosphoSitePlus as discussed by the authors is an open, comprehensive, manually curated and interactive resource for studying experimentally observed post-translational modifications, primarily of human and mouse proteins.
Journal ArticleDOI
The BioPAX community standard for pathway data sharing
Emek Demir,Emek Demir,Michael P. Cary,Suzanne M. Paley,Ken Fukuda,Christian Lemer,Imre Vastrik,Guanming Wu,Peter D'Eustachio,Carl F. Schaefer,Joanne S. Luciano,Frank Schacherer,Irma Martínez-Flores,Zhenjun Hu,Verónica Jiménez-Jacinto,Geeta Joshi-Tope,Kumaran Kandasamy,Alejandra López-Fuentes,Huaiyu Mi,Elgar Pichler,Igor Rodchenkov,Andrea Splendiani,Andrea Splendiani,Sasha Tkachev,Jeremy Zucker,Gopal R. Gopinath,Harsha Rajasimha,Harsha Rajasimha,Ranjani Ramakrishnan,Imran Shah,Mustafa H Syed,Nadia Anwar,Özgün Babur,Özgün Babur,Michael L. Blinov,Erik Brauner,Dan Corwin,Sylva L. Donaldson,Frank Gibbons,Robert N. Goldberg,Peter Hornbeck,Augustin Luna,Peter Murray-Rust,Eric K. Neumann,Oliver Reubenacker,Matthias Samwald,Matthias Samwald,Martijn P. van Iersel,Sarala M. Wimalaratne,Keith Allen,Burk Braun,Michelle Whirl-Carrillo,Kei-Hoi Cheung,Kam D. Dahlquist,Andrew Finney,Marc Gillespie,Elizabeth M. Glass,Li Gong,Robin Haw,Michael Honig,Olivier Hubaut,David W. Kane,Shiva Krupa,Martina Kutmon,Julie Leonard,Debbie Marks,David Merberg,Victoria Petri,Alexander R. Pico,Dean Ravenscroft,Liya Ren,Nigam H. Shah,Margot Sunshine,Rebecca Tang,Ryan Whaley,Stan Letovksy,Kenneth H. Buetow,Andrey Rzhetsky,Vincent Schächter,Bruno S. Sobral,Ugur Dogrusoz,Shannon K. McWeeney,Mirit I. Aladjem,Ewan Birney,Julio Collado-Vides,Susumu Goto,Michael Hucka,Nicolas Le Novère,Natalia Maltsev,Akhilesh Pandey,Paul Thomas,Edgar Wingender,Peter D. Karp,Chris Sander,Gary D. Bader +94 more
TL;DR: Thousands of interactions, organized into thousands of pathways, from many organisms are available from a growing number of databases, and this large amount of pathway data in a computable form will support visualization, analysis and biological discovery.
Journal ArticleDOI
PhosphoSite: A bioinformatics resource dedicated to physiological protein phosphorylation.
TL;DR: As it develops into a comprehensive resource of known in vivo phosphorylation sites, it is expected that PhosphoSite will be a valuable tool for researchers seeking to understand the role of intracellular signaling pathways in a wide variety of biological processes.
Journal ArticleDOI
Akt–RSK–S6 Kinase Signaling Networks Activated by Oncogenic Receptor Tyrosine Kinases
Albrecht Moritz,Yu Li,Ailan Guo,Judit Villén,Yi Wang,Joan MacNeill,Jon M. Kornhauser,Kam Sprott,Jing Zhou,Anthony Possemato,Jian Min Ren,Peter Hornbeck,Lewis C. Cantley,Lewis C. Cantley,Steven P. Gygi,John Rush,Michael J. Comb +16 more
TL;DR: A phosphoproteomic approach to identify targets of three core signaling pathways—all of which involve activation of AGC family kinases—downstream of oncogenic RTKs is developed, revealing previously unidentified Akt–RSK–S6 kinase substrates that merit further consideration as targets for combination therapy with RTKIs.