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Erik Vegt
Researcher at Radboud University Nijmegen Medical Centre
Publications - 15
Citations - 754
Erik Vegt is an academic researcher from Radboud University Nijmegen Medical Centre. The author has contributed to research in topics: Kidney & Radionuclide therapy. The author has an hindex of 8, co-authored 10 publications receiving 670 citations.
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Journal ArticleDOI
Renal Toxicity of Radiolabeled Peptides and Antibody Fragments: Mechanisms, Impact on Radionuclide Therapy, and Strategies for Prevention
Erik Vegt,Marion de Jong,Jack F.M. Wetzels,Rosalinde Masereeuw,Marleen Melis,Wim J.G. Oyen,Martin Gotthardt,Otto C. Boerman +7 more
TL;DR: An overview of renal handling of radiolabeled peptides and resulting nephrotoxicity is presented, and strategies to reduce neph rotoxicity are discussed.
Journal Article
Gelatin-Based Plasma Expander Effectively Reduces Renal Uptake of 111In-Octreotide in Mice and Rats
Julliëtte E.M. van Eerd,Erik Vegt,Jack F.M. Wetzels,Frans G. M. Russel,Rosalinde Masereeuw,Frans H.M. Corstens,Wim J.G. Oyen,Otto C. Boerman +7 more
TL;DR: Gelofusine is a well-known and generally used blood volume substitute that can be applied safely without the induction of toxicity, and evaluation of this compound for its potential to reduce the kidney uptake of radiolabeled peptides in patients is warranted.
Journal ArticleDOI
Renal uptake of different radiolabelled peptides is mediated by megalin: SPECT and biodistribution studies in megalin-deficient mice
Erik Vegt,Marleen Melis,Annemarie Eek,Monique de Visser,Maarten Brom,Wim J.G. Oyen,Martin Gotthardt,Marion de Jong,Otto C. Boerman +8 more
TL;DR: Megalin is involved in the renal reabsorption of radiolabelled octreotide, octreotate, exendin, neurotensin and minigastrin, and knowledge may help in the design of strategies to reduce this re absorption and the resulting nephrotoxicity in peptide receptor radionuclide therapy, enabling more effective therapy.
Journal Article
Renal Uptake of Radiolabeled Octreotide in Human Subjects Is Efficiently Inhibited by Succinylated Gelatin
Erik Vegt,Jack F.M. Wetzels,Frans G. M. Russel,Rosalinde Masereeuw,Otto C. Boerman,Juliette E.M. van Eerd,Frans H.M. Corstens,Wim J.G. Oyen +7 more
TL;DR: It is observed that gelatin-based plasma expanders induced tubular low-molecular-weight proteinuria in healthy volunteers, suggesting that components in these solutions can interfere with the tubular reabsorption of proteins and peptides.
Journal ArticleDOI
Reducing Renal Uptake of Radiolabeled Peptides Using Albumin Fragments
Erik Vegt,Julliëtte E.M. van Eerd,Annemarie Eek,Wim J.G. Oyen,Jack F.M. Wetzels,Marion de Jong,Frans G. M. Russel,Rosalinde Masereeuw,Martin Gotthardt,Otto C. Boerman +9 more
TL;DR: Renal uptake of 111In-octreotide and other radiolabeled peptides in rats can be effectively reduced by administration of albumin fragments, as well as the effect of lysine, succinylated gelatin solution, albumin, and FRALB on the kidney uptake.