M
Maarten Brom
Researcher at Radboud University Nijmegen
Publications - 62
Citations - 1595
Maarten Brom is an academic researcher from Radboud University Nijmegen. The author has contributed to research in topics: Beta cell & In vivo. The author has an hindex of 18, co-authored 55 publications receiving 1367 citations. Previous affiliations of Maarten Brom include Radboud University Nijmegen Medical Centre.
Papers
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Journal ArticleDOI
Spatial Resolution and Sensitivity of the Inveon Small-Animal PET Scanner
Eric P. Visser,Jonathan A. Disselhorst,Maarten Brom,Peter Laverman,Martin Gotthardt,Wim J.G. Oyen,Otto C. Boerman +6 more
TL;DR: The Inveon showed high spatial resolution and high sensitivity, both of which can be maintained using OSEM3D/MAP reconstruction instead of rebinning and 2D algorithms.
Journal ArticleDOI
Image-Quality Assessment for Several Positron Emitters Using the NEMA NU 4-2008 Standards in the Siemens Inveon Small-Animal PET Scanner
Jonathan A. Disselhorst,Maarten Brom,Peter Laverman,Cornelius H. Slump,Otto C. Boerman,Wim J.G. Oyen,Martin Gotthardt,Eric P. Visser +7 more
TL;DR: With the intrinsic spatial resolution (≈1.5 mm) of this latest-generation small-animal PET scanner, the finite positron range has become the limiting factor for the overall spatial resolution and activity recovery in small structures imaged with 124I and 68Ga.
Journal ArticleDOI
Non-invasive quantification of the beta cell mass by SPECT with 111In-labelled exendin
Maarten Brom,Wietske Woliner-van der Weg,Lieke Joosten,Cathelijne Frielink,Thomas Bouckenooghe,Thomas Bouckenooghe,P.F.J.W. Rijken,Karolina M. Andralojc,Burkhard Göke,Marion de Jong,Decio L. Eizirik,Martin Béhé,Tony Lahoutte,Wim J.G. Oyen,Cees J. Tack,Marcel J.R. Janssen,Otto C. Boerman,Martin Gotthardt +17 more
TL;DR: These studies indicate that 111In-labelled exendin may be suitable for non-invasive quantification of BCM in vivo in a rodent model of beta cell loss and in patients with type 1 diabetes and healthy individuals.
Journal ArticleDOI
68Ga-labelled exendin-3, a new agent for the detection of insulinomas with PET
TL;DR: In this murine tumour model optimal targeting of the GLP-1R expressing tumour was obtained at exendin doses ≤0.1 µg and in vivo targeting was investigated in BALB/c nude mice with subcutaneous INS-1 tumours.
Journal ArticleDOI
Renal uptake of different radiolabelled peptides is mediated by megalin: SPECT and biodistribution studies in megalin-deficient mice
Erik Vegt,Marleen Melis,Annemarie Eek,Monique de Visser,Maarten Brom,Wim J.G. Oyen,Martin Gotthardt,Marion de Jong,Otto C. Boerman +8 more
TL;DR: Megalin is involved in the renal reabsorption of radiolabelled octreotide, octreotate, exendin, neurotensin and minigastrin, and knowledge may help in the design of strategies to reduce this re absorption and the resulting nephrotoxicity in peptide receptor radionuclide therapy, enabling more effective therapy.