Erik Vegt

TL;DR: An overview of renal handling of radiolabeled peptides and resulting nephrotoxicity is presented, and strategies to reduce neph rotoxicity are discussed.

TL;DR: Gelofusine is a well-known and generally used blood volume substitute that can be applied safely without the induction of toxicity, and evaluation of this compound for its potential to reduce the kidney uptake of radiolabeled peptides in patients is warranted.

TL;DR: Megalin is involved in the renal reabsorption of radiolabelled octreotide, octreotate, exendin, neurotensin and minigastrin, and knowledge may help in the design of strategies to reduce this re absorption and the resulting nephrotoxicity in peptide receptor radionuclide therapy, enabling more effective therapy.

TL;DR: It is observed that gelatin-based plasma expanders induced tubular low-molecular-weight proteinuria in healthy volunteers, suggesting that components in these solutions can interfere with the tubular reabsorption of proteins and peptides.

TL;DR: Renal uptake of 111In-octreotide and other radiolabeled peptides in rats can be effectively reduced by administration of albumin fragments, as well as the effect of lysine, succinylated gelatin solution, albumin, and FRALB on the kidney uptake.