Erinna F. Lee

Journal ArticleDOI

Peptide Inhibitors of the Malaria Surface Protein, Apical Membrane Antigen 1: Identification of Key Binding Residues

- 01 May 2011 -

TL;DR: The identification of a nonpolar region of these peptides containing residues essential for AMA1 binding establishes a basis for the design of anti‐malarial drugs based on R1 mimetics.

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Journal ArticleDOI

BCL-XL is an actionable target for treatment of malignant pleural mesothelioma.

Surein Arulananda, +17 more

- 31 Oct 2020 -

Cell death discovery

TL;DR: It is found BCL-XL is the dominant pro-survival protein in a panel of cell lines in vitro, though potent, synergistic cell killing occurred with MCL-1 co-targeting, and in vivo B CL-XL inhibition was as effective as Cisplatin, and the combination enhanced tumour growth control and survival.

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Journal ArticleDOI

Direct visualization of Bcl-2 family protein interactions using live cell fluorescent protein redistribution assays

Chihunt Wong, +6 more

- 29 Mar 2012 -

Cell Death and Disease

TL;DR: Direct visualization of Bcl-2 family protein interactions using live cell fluorescent protein redistribution assays as discussed by the authors is shown in Fig. 1, where the Bcl2 family is represented as a set of cells.

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Journal ArticleDOI

Co-Operativity between MYC and BCL-2 Pro-Survival Proteins in Cancer.

W.D. Fairlie, +1 more

- 11 Mar 2021 -

International Journal of Molecular Scien...

TL;DR: In this paper, the individual roles of both proteins in cancer, describe cancers where co-operativity between them has been well-characterised and finally, some strategies to target these proteins therapeutically.

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