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W. Douglas Fairlie

Researcher at La Trobe University

Publications -  77
Citations -  14535

W. Douglas Fairlie is an academic researcher from La Trobe University. The author has contributed to research in topics: Protein structure & Programmed cell death. The author has an hindex of 38, co-authored 71 publications receiving 12384 citations. Previous affiliations of W. Douglas Fairlie include University of Melbourne & Walter and Eliza Hall Institute of Medical Research.

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Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

Daniel J. Klionsky, +2522 more
- 21 Jan 2016 - 
TL;DR: In this paper, the authors present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macro-autophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.
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Apoptosis Initiated When BH3 Ligands Engage Multiple Bcl-2 Homologs, Not Bax or Bak

Simon N. Willis, +15 more
- 09 Feb 2007 - 
TL;DR: Contrary to the direct-activation model, it is shown that Bax and Bak can mediate apoptosis without discernable association with the putative BH3-only activators (Bim, Bid, and Puma).
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Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)

Daniel J. Klionsky, +2983 more
- 08 Feb 2021 - 
TL;DR: In this article, the authors present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes.
Journal ArticleDOI

MIC-1, a novel macrophage inhibitory cytokine, is a divergent member of the TGF-β superfamily

Michelle Bootcov, +15 more
- 14 Oct 1997 - 
TL;DR: Purified recombinant MIC-1 is able to inhibit lipopolysaccharide -induced macrophage TNF-alpha production, suggesting that MIC- 1 acts in macrophages as an autocrine regulatory molecule.
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Tumor-induced anorexia and weight loss are mediated by the TGF-beta superfamily cytokine MIC-1.

Heiko Johnen, +23 more
- 01 Nov 2007 - 
TL;DR: Macrophage inhibitory cytokine-1 is a newly defined central regulator of appetite and a potential target for the treatment of both cancer anorexia and weight loss, as well as of obesity.