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Ermias Mekuria Addo
Researcher at Ohio State University
Publications - 8
Citations - 153
Ermias Mekuria Addo is an academic researcher from Ohio State University. The author has contributed to research in topics: Biology & Zebrafish. The author has an hindex of 4, co-authored 6 publications receiving 85 citations. Previous affiliations of Ermias Mekuria Addo include College of Health Sciences, Bahrain.
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Current status and contemporary approaches to the discovery of antitumor agents from higher plants.
TL;DR: Higher plant constituents have afforded clinically available anticancer drugs, including both chemically unmodified small molecules and their synthetic derivatives currently used or those in clinical trials as antineoplastic agents, and an updated summary is provided.
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Highly sweet compounds of plant origin: From ethnobotanical observations to wide utilization
TL;DR: Initial observations on the ethnobotany of both S. rebaudiana and S. grosvenorii have proved crucial to indicating the presence of their sweet-tasting principles to the wider scientific community, and recent phytochemical work on the sweet principles of these two species is highlighted.
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Antiproliferative Constituents of the Roots of Ethiopian Podocarpus falcatus and Structure Revision of 2α-Hydroxynagilactone F and Nagilactone I.
Ermias Mekuria Addo,Ermias Mekuria Addo,Heebyung Chai,Ariaya Hymete,Mariamawit Yonathan Yeshak,Carla Slebodnick,David G. I. Kingston,L. Harinantenaina Rakotondraibe +7 more
TL;DR: Among the isolated compounds, the nagilactones, including the new dilactones 16-hydroxynagilACTone F (1) and 2β,16-dihydroxynAGilact one F (2), were the most active against the HT-29 cell line, whereas the bisditerpenoids and the other known compounds 9 and 10 were inactive.
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Caspase-Dependent Apoptosis in Prostate Cancer Cells and Zebrafish by Corchorusoside C from Streptocaulon juventas.
Gerardo D. Anaya-Eugenio,Ermias Mekuria Addo,Nathan Ezzone,Joshua M. Henkin,Tran Ngoc Ninh,Yulin Ren,Djaja D. Soejarto,A. Douglas Kinghorn,Esperanza J. Carcache de Blanco +8 more
TL;DR: Corchorusoside C (1) induces apoptosis in DU-145 cells and targets the same pathways both in vitro and in vivo in zebrafish, and seems worthy of wider application than is currently employed for the evaluation of potential anticancer agents of natural origin.
Journal ArticleDOI
Spermidine alkaloid and glycosidic constituents of Vietnamese Homalium cochinchinensis.
Ermias Mekuria Addo,Yulin Ren,Gerardo D. Anaya-Eugenio,Tran Ngoc Ninh,Harinantenaina L. Rakotondraibe,Esperanza J. Carcache de Blanco,Djaja D. Soejarto,Djaja D. Soejarto,A. Douglas Kinghorn +8 more
TL;DR: In this paper, the structural elucidation of these unprecedented secondary metabolites (1-8) is described, and the structures of all new isolates were determined by interpretation of spectroscopic and spectrometric data.