S
Sylvie Mader
Researcher at Université de Montréal
Publications - 112
Citations - 10518
Sylvie Mader is an academic researcher from Université de Montréal. The author has contributed to research in topics: Estrogen receptor & Estrogen receptor alpha. The author has an hindex of 40, co-authored 107 publications receiving 9904 citations. Previous affiliations of Sylvie Mader include McGill University & French Institute of Health and Medical Research.
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Journal ArticleDOI
Cutting Edge: 1,25-dihydroxyvitamin D3 Is a Direct Inducer of Antimicrobial Peptide Gene Expression
Tian-Tian Wang,Frederick P. Nestel,Véronique Bourdeau,Yoshihiko Nagai,Qiuyu Wang,Jie Liao,Luz E. Tavera-Mendoza,Roberto Lin,John H. Hanrahan,Sylvie Mader,John H. White +10 more
TL;DR: 1,25(OH)2D3 thus directly regulates antimicrobial peptide gene expression, revealing the potential of its analogues in treatment of opportunistic infections.
Journal ArticleDOI
Purification, cloning, and RXR identity of the HeLa cell factor with which RAR or TR heterodimerizes to bind target sequences efficiently
Mark Leid,Mark Leid,Philippe Kastner,Philippe Kastner,Ruth Lyons,Ruth Lyons,Harikrishna Nakshatri,Harikrishna Nakshatri,Michael Saunders,Michael Saunders,Tim Zacharewski,Tim Zacharewski,Jia Yang Chen,Jia Yang Chen,Adrien Staub,Adrien Staub,Jean Marie Garnier,Jean Marie Garnier,Sylvie Mader,Sylvie Mader,Pierre Chambon,Pierre Chambon +21 more
TL;DR: It is shown that unstable RAR-RXR heterodimers were formed in solution, and that C-terminal sequences and the DNA-binding domains of both receptors were required for efficient formation of stable heterodIMers on response elements.
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The translation initiation factor eIF-4E binds to a common motif shared by the translation factor eIF-4 gamma and the translational repressors 4E-binding proteins.
TL;DR: Light is shed on the mechanisms of eIF-4F assembly and on the translational regulation by insulin and growth factors and a 12-amino-acid sequence conserved between mammals and Saccharomyces cerevisiae that is critical for the interaction with eif-4E is identified.
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Repression of cap-dependent translation by 4E-binding protein 1: competition with p220 for binding to eukaryotic initiation factor-4E.
TL;DR: Translational control by growth factors, insulin and mitogens is affected by changes in the relative affinities of 4E‐BP1 and p220 for eIF‐4E, and the mechanism by which 4E-BP1 inhibits translation is studied.
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Large-scale in silico and microarray-based identification of direct 1,25-dihydroxyvitamin D3 target genes.
Tian-Tian Wang,Luz E. Tavera-Mendoza,David Laperrière,Eric Libby,Naomi Burton MacLeod,Yoshihiko Nagai,Véronique Bourdeau,Anna Konstorum,Benjamin Lallemant,Rui Zhang,Sylvie Mader,John H. White +11 more
TL;DR: The combined approaches used here provide numerous insights into the direct target genes underlying the broad physiological actions of 1,25(OH)2D3.