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Ernst Schönbrunn
Researcher at University of South Florida
Publications - 91
Citations - 5094
Ernst Schönbrunn is an academic researcher from University of South Florida. The author has contributed to research in topics: Bromodomain & Kinase. The author has an hindex of 35, co-authored 84 publications receiving 4409 citations. Previous affiliations of Ernst Schönbrunn include University of Kansas & University of California, Berkeley.
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Journal ArticleDOI
Interaction of the herbicide glyphosate with its target enzyme 5-enolpyruvylshikimate 3-phosphate synthase in atomic detail
Ernst Schönbrunn,Susanne Eschenburg,Wendy A. Shuttleworth,John V. Schloss,Nikolaus Amrhein,Jeremy N.S. Evans,Wolfgang Kabsch +6 more
TL;DR: The elucidation of the active site of EPSP synthase and especially of the binding pattern of glyphosate provides a valuable roadmap for engineering new herbicides and herbicide-resistant crops, as well as new antibiotic and antiparasitic drugs.
Journal ArticleDOI
The crystal structure of dimeric kinesin and implications for microtubule-dependent motility.
Frank Kozielski,S. Sack,A Marx,M. Thormahlen,Ernst Schönbrunn,V. Biou,A. Thompson,Eckhard Mandelkow,Eva-Maria Mandelkow +8 more
TL;DR: The dimeric form of the kinesin motor and neck domain from rat brain with bound ADP has been solved by X-ray crystallography and is unexpected since it is not compatible with the microtubule lattice.
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Molecular basis for the herbicide resistance of Roundup Ready crops.
TL;DR: The CP4 enzyme has unexpected kinetic and structural properties that render it unique among the known EPSP synthases, and can be restored through a single-site mutation in the active site (Ala-100–Gly), allowing glyphosate to bind in its extended, inhibitory conformation.
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Acetyl-lysine Binding Site of Bromodomain-Containing Protein 4 (BRD4) Interacts with Diverse Kinase Inhibitors.
S.W. Ember,Jin-Yi Zhu,S.H. Olesen,Mathew P. Martin,Andreas Becker,Norbert Berndt,Gunda I. Georg,Ernst Schönbrunn +7 more
TL;DR: Comparative structural analysis revealed markedly different binding modes of kinase hinge-binding scaffolds in the KAc binding site, suggesting that BET proteins are potential off-targets of diverse kinase inhibitors.
Journal ArticleDOI
Molecular basis of glyphosate resistance – different approaches through protein engineering
TL;DR: Glyphosate (N-phosphonomethyl-glycine) is the most widely used herbicide in the world: glyphosate-based formulations exhibit broad-spectrum herbicidal activity with minimal human and environmental toxicity as mentioned in this paper.