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Errol B. De Souza

Researcher at National Institute on Drug Abuse

Publications -  60
Citations -  4038

Errol B. De Souza is an academic researcher from National Institute on Drug Abuse. The author has contributed to research in topics: Receptor & Pituitary gland. The author has an hindex of 34, co-authored 60 publications receiving 3988 citations. Previous affiliations of Errol B. De Souza include Loyola University Chicago & Johns Hopkins University.

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Corticotrophin-releasing factor receptors: from molecular biology to drug design

Derek T. Chalmers, +4 more
- 01 Apr 1996 - 
TL;DR: The major differences between the two classes of CRF receptors, CRF1 and CRF2, and a functionally related CRF-binding protein are highlighted, and the relevance of these sites to the ongoing development ofCRF-based therapeutics is discussed.
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MDMA-induced neurotoxicity: parameters of degeneration and recovery of brain serotonin neurons.

George Battaglia, +2 more
- 01 Feb 1988 - 
TL;DR: The neurodegenerative effects of MDMA on5-HT neurons exhibited some species specificity as comparable decreases in cerebral cortical 5-HT, 5-HIAA and 5- HT uptake sites were observed in rat and guinea pig while no significant changes in any of these serotonergic parameters were seen in mouse brain.
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Pharmacologic profile of MDMA (3,4-methylenedioxymethamphetamine) at various brain recognition sites

George Battaglia, +3 more
- 27 Apr 1988 - 
TL;DR: MDMA exhibited negligible affinities (greater than 500 microM) at opioid (mu, delta and kappa), central-type benzodiazepine, and corticotropin-releasing factor receptors, and at choline uptake sites and calcium channels.
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Reciprocal changes in corticotropin-releasing factor (CRF)-like immunoreactivity and CRF receptors in cerebral cortex of Alzheimer's disease.

Errol B. De Souza, +6 more
- 01 Feb 1986 - 
TL;DR: In Alzheimer’s, the concentrations of CRF-like immunoreactivity (CRF-IR) are reduced and that there are reciprocal increases in CRF receptor binding in affected cortical areas, which strongly support a neurotransmitter role for CRF in brain and demonstrate, for the first time, a modulation of CNS CRF receptors associated with altered CRF content.
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Peripheral-Type Benzodiazepine Receptors in Endocrine Organs: Autoradiographic Localization in Rat Pituitary, Adrenal, and Testis*

Errol B. De Souza, +4 more
- 01 Feb 1985 - 
TL;DR: A differential and discrete localization of peripheral-type benzodiazepine receptors in rat pituitary, adrenal, and testis is demonstrated.