E
Esteban Nicolas Gurzov
Researcher at University of Pisa
Publications - 3
Citations - 193
Esteban Nicolas Gurzov is an academic researcher from University of Pisa. The author has contributed to research in topics: Interleukin & NFKB1. The author has an hindex of 2, co-authored 3 publications receiving 171 citations.
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Peripheral and Islet Interleukin-17 Pathway Activation Characterizes Human Autoimmune Diabetes and Promotes Cytokine-Mediated β-Cell Death
Sefina Arif,Fabrice Moore,Katherine Marks,Thomas Bouckenooghe,Colin M. Dayan,Raquel Planas,Marta Vives-Pi,Jake Powrie,Timothy Tree,Piero Marchetti,Guo Cai Huang,Esteban Nicolas Gurzov,Ricardo Pujol-Borrell,Decio L. Eizirik,Mark Peakman +14 more
TL;DR: It is shown that IL-17 mediates significant and reproducible enhancement of IL-1β/interferon (IFN)-γ–induced and tumor necrosis factor (TNF)-α/IFN-γ-induced apoptosis in human islets, rat β-cells, and INS-1E cells, in association with significant upregulation of β-cell IL17RA expression via activation of the transcription factors STAT1 and nuclear factor (NF)-κB.
Journal Article
Differential usage of NF-kB activating signals by IL-1b and TNF-a in pancreatic beta cells
Fernanda Ortis,Michela Miani,Maikel Luis Colli,Daniel Andrade Da Cunha,Esteban Nicolas Gurzov,Florent Allagnat,Alain Chariot,Decio L. Eizirik +7 more
TL;DR: A differential usage of the IKK complex by IL‐1β and TNF‐α in β‐cells in type 1 diabetes is shown, achieved by induction of IKKβ degradation via the proteasome.