Jake Powrie

TL;DR: The citations in retrieved papers were examined and non-English language papers were included as too few articles were retrieved by searches restricted to English language publications only.

TL;DR: In this article, the authors evaluated the effectiveness of self-monitoring of blood or urine glucose at improving blood glucose control through a systematic review and meta-analysis, and concluded that the results do not provide evidence for clinical effectiveness of an item of care with appreciable costs.

TL;DR: It is shown that IL-17 mediates significant and reproducible enhancement of IL-1β/interferon (IFN)-γ–induced and tumor necrosis factor (TNF)-α/IFN-γ-induced apoptosis in human islets, rat β-cells, and INS-1E cells, in association with significant upregulation of β-cell IL17RA expression via activation of the transcription factors STAT1 and nuclear factor (NF)-κB.

TL;DR: It is concluded that different immunopathological processes (endotypes) may underlie type 1 diabetes, carrying important implications for treatment and prevention strategies.

TL;DR: Proinsulin peptide immunotherapy is safe, does not accelerate decline in β cell function, and is associated with antigen-specific and nonspecific immune modulation.