E
Esther Garde
Researcher at Spanish National Research Council
Publications - 12
Citations - 188
Esther Garde is an academic researcher from Spanish National Research Council. The author has contributed to research in topics: Visceral leishmaniasis & Leishmania infantum. The author has an hindex of 8, co-authored 12 publications receiving 163 citations.
Papers
More filters
Journal ArticleDOI
Prophylactic properties of a Leishmania-specific hypothetical protein in a murine model of visceral leishmaniasis.
Daniela P. Lage,Vívian T. Martins,Mariana C. Duarte,Esther Garde,Miguel A. Chávez-Fumagalli,Daniel Menezes-Souza,Bruno Mendes Roatt,Carlos Alberto Pereira Tavares,Manuel Soto,Eduardo A.F. Coelho +9 more
TL;DR: Results indicate that the new LiHyD protein could be considered in vaccine formulations against VL and was correlated with the Leishmania‐specific production on nitric oxide.
Journal ArticleDOI
Antigenicity, Immunogenicity and Protective Efficacy of Three Proteins Expressed in the Promastigote and Amastigote Stages of Leishmania infantum against Visceral Leishmaniasis
Vívian T. Martins,Miguel A. Chávez-Fumagalli,Daniela P. Lage,Mariana C. Duarte,Esther Garde,Lourena E. Costa,Viviane Grazielle Silva,Jamil S. Oliveira,Danielle F. de Magalhães-Soares,Santuza M. R. Teixeira,Ana Paula Fernandes,Manuel Soto,Carlos Alberto Pereira Tavares,Eduardo A.F. Coelho +13 more
TL;DR: The immunogenicity and protective efficacy of the three proteins administered in the presence of saponin, individually or in combination (composing a polyproteins vaccine), were evaluated in a VL murine model: BALB/c mice infected with L. infantum.
Journal ArticleDOI
A new Leishmania -specific hypothetical protein and its non-described specific B cell conformational epitope applied in the serodiagnosis of canine visceral leishmaniasis
Daniela P. Lage,Vívian T. Martins,Mariana C. Duarte,Lourena E. Costa,Esther Garde,Laura Mattos Dimer,Amanda Christine Da Silva Kursancew,Miguel A. Chávez-Fumagalli,Danielle F. de Magalhães-Soares,Daniel Menezes-Souza,Bruno Mendes Roatt,Ricardo Andrez Machado-de-Ávila,Manuel Soto,Carlos Alberto Pereira Tavares,Eduardo A.F. Coelho +14 more
TL;DR: The rLiHyD presented better results for the CVL serodiagnosis than its linear epitopes, although the peptide recreating the conformational epitope resulted also appropriate as a diagnostic marker of CVL.
Journal ArticleDOI
Evaluation of two recombinant Leishmania proteins identified by an immunoproteomic approach as tools for the serodiagnosis of canine visceral and human tegumentary leishmaniasis.
Eduardo A.F. Coelho,Lourena E. Costa,Daniela P. Lage,Vívian T. Martins,Esther Garde,Nathália Cristina de Jesus Pereira,Eliane Gonçalves Paiva Lopes,Luiz Felipe Nunes Menezes Borges,Mariana C. Duarte,Daniel Menezes-Souza,Danielle F. de Magalhães-Soares,Miguel A. Chávez-Fumagalli,Manuel Soto,Carlos Alberto Pereira Tavares +13 more
TL;DR: ELISA assays using the recombinant proteins showed both sensitivity and specificity values of 100% for the serodiagnosis of both forms of disease, with high positive and negative predictive values, showing better diagnostic properties than the parasite recombinant A2 protein or a soluble Leishmania antigen extract.
Journal ArticleDOI
A new Leishmania-specific hypothetical protein, LiHyT, used as a vaccine antigen against visceral leishmaniasis.
Vívian T. Martins,Daniela P. Lage,Mariana C. Duarte,Lourena E. Costa,Esther Garde,Marcella Rezende Rodrigues,Miguel A. Chávez-Fumagalli,Daniel Menezes-Souza,Bruno Mendes Roatt,Carlos Alberto Pereira Tavares,Manuel Soto,Eduardo A.F. Coelho +11 more
TL;DR: It is shown that a new Leishmania-specific protein, when combined with a Th1-type adjuvant, presents potential to be used as a vaccine against VL.