C
Carlos Alberto Pereira Tavares
Researcher at Universidade Federal de Minas Gerais
Publications - 89
Citations - 2657
Carlos Alberto Pereira Tavares is an academic researcher from Universidade Federal de Minas Gerais. The author has contributed to research in topics: Visceral leishmaniasis & Leishmania infantum. The author has an hindex of 28, co-authored 88 publications receiving 2350 citations.
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Journal ArticleDOI
Immune responses induced by the Leishmania (Leishmania) donovani A2 antigen, but not by the LACK antigen, are protective against experimental Leishmania (Leishmania) amazonensis infection
Eduardo A.F. Coelho,Carlos Alberto Pereira Tavares,Fernando A. A. Carvalho,Karina Figueiredo Chaves,Kadima Nayara Teixeira,Rafaela Chitarra Rodrigues,Hugues Charest,Greg Matlashewski,Ricardo T. Gazzinelli,Ana Paula Fernandes +9 more
TL;DR: A2, but not LACK, fits the requirements for a safe vaccine against American leishmaniasis, and the association between rA2 and rLACK antigens in the same vaccine completely inhibited the rA 2-specific IFN-γ and humoral responses and, consequently, the protective effect of the r a2 antigen against L. amazonensis infection.
Journal ArticleDOI
Diagnosis of American visceral leishmaniasis in humans and dogs using the recombinant Leishmania donovani A2 antigen.
Fernando A. A. Carvalho,Hugues Charest,Carlos Alberto Pereira Tavares,Greg Matlashewski,Eneida P. Valente,Ana Rabello,Ricardo T. Gazzinelli,Ricardo T. Gazzinelli,Ana Paula Fernandes +8 more
TL;DR: The findings suggest that A2 protein is a potential tool for the diagnosis of VL in the New World, and will be particularly useful for diagnosis of dogs.
Journal ArticleDOI
Antigenicity and Protective Efficacy of a Leishmania Amastigote-specific Protein, Member of the Super-oxygenase Family, against Visceral Leishmaniasis
Vívian T. Martins,Miguel A. Chávez-Fumagalli,Lourena E. Costa,Adriana Monte Cassiano Canavaci Martins,Paula S. Lage,Daniela P. Lage,Mariana C. Duarte,Diogo G. Valadares,Rubens Daniel Miserani Magalhães,Tatiana G. Ribeiro,Ronaldo Alves Pinto Nagem,Wanderson D. DaRocha,Wiliam César Bento Régis,Manuel Soto,Eduardo A.F. Coelho,Ana Paula Fernandes,Carlos Alberto Pereira Tavares +16 more
TL;DR: It is shown that this Leishmania oxygenase amastigote-specific protein can be used for a more sensitive and specific serodiagnosis of asymptomatic and symptomatic CVL and, when combined with a Th1-type adjuvant, can also be employ as a candidate antigen to develop vaccines against VL.
Journal ArticleDOI
Identification of Proteins in Promastigote and Amastigote-like Leishmania Using an Immunoproteomic Approach
Vinicio T.S. Coelho,Jamil S. Oliveira,Diogo G. Valadares,Miguel A. Chávez-Fumagalli,Mariana C. Duarte,Paula S. Lage,Manuel Soto,Marcelo M. Santoro,Carlos Alberto Pereira Tavares,Ana Paula Fernandes,Eduardo A.F. Coelho +10 more
TL;DR: A significant contribution not only in identifying stage-specific L. infantum molecules, but also in revealing the expression of a large number of hypothetical proteins that constitute a significant source of information for the improvement of diagnostic tools and/or vaccine development to VL.
Journal ArticleDOI
Molecular diagnosis of leishmaniasis.
TL;DR: This review describes the worldwide situation of visceral and tegumentary leishmaniasis with an emphasis on diagnosis, including methods for the detection of antibodies, antigens, parasite DNA and of skin testing.