Eugen Faist

TL;DR: The hypothesis that autologous blood transfusion does not contain immunologically neutral effects of allogeneic blood, but itself exerts an immunomodulatory effect is supported.

TL;DR: Filgrastim treatment reinforces innate immunity, enabling better prevention of infection, and this unique combination of hematopoietic, anti-inflammatory and anti-infectious effects on the innate immune system warrants further study of clinical efficacy and sepsis prophylaxis.

TL;DR: Significantly higher filtration rates may be required to improve left ventricular contractility in patients with sepsis by hemofiltration, which induced significant cardiotoxic effects in rat cardiomyocytes whereas UFh showed no cardiotoxicity.

TL;DR: The data corroborate that major burn trauma will induce a significant shift of cytokine response toward the TH2 direction and demonstrate that the CD8+ rather than the CD4+ phenotype is the crucial cell for the polarization toward a TH2-driven immune response.

TL;DR: This study clearly demonstrates that the combined Indo/TP-5 therapy is superior to single Indo administration and can adequately preserve and/or restore intact M phi T-cell interaction and thus appears to be a feasible approach to maintain normal host defense activity in traumatized individuals.