Eugen Faist

TL;DR: It is demonstrated that the endogenous alarmins MRP8 and MRP14 induce phagocyte hyporesponsiveness via chromatin modifications in a TLR4-dependent manner that results in enhanced survival to septic shock in mice.

TL;DR: The results demonstrate the impairment of the functional capacity of circulating monocytes and that the degree of functional impairment is proportional to the severity of the injury.

TL;DR: The study was performed to further elucidate the mechanisms of dysfunctional T- cell activation following extensive burn and mechanical injuries and to scrutinize if inadequate lymphokine production after trauma is possibly a result of defective transduction of extracellular signals to the T-cell nucleus.

TL;DR: Results indicate a significant suppression of TH1-induced cell-mediated immune response following CPB, while TH2-induced response remains normal, which may be helpful for recovery following cardiac surgery by cleaning the body of the byproducts of CPB.

TL;DR: Human lymphocytic interleukin-2 synthesis, which represents the key event among forward regulatory immune mechanisms, can be protected via in vivo immunoaugmentatory therapy and that this therapy can successfully counteract immunosuppressive effects of cardiopulmonary bypass is demonstrated.