Eva Huysmans

TL;DR: The available evidence supports various pharmacological and non-pharmacological strategies to reduce central sensitisation and to improve patient outcomes in several conditions commonly seen in rheumatology practice and studies suggest the possibility of matching non-Pharmacological approaches, or medications, or both to thecentral sensitisation pain phenotypes.

TL;DR: This review focused on preclinical work and mostly on the neurobiochemistry studied in animals, with limited human studies available, to explore the mechanisms of sensitization of the central nervous system in chronic pain patients.

TL;DR: The treatment rationale based on the complex mechanisms underlying CS in patients having chronic pain is presented and emphasis is given to explaining the concept of CS when providing treatment, as well as why patients and clinicians should focus on long-term rather than short-term treatment effects.

TL;DR: The International Association for the Study of Pain (IASP) released clinical criteria and a grading system for nociplastic pain affecting the musculoskeletal system as mentioned in this paper.

TL;DR: A state-of-the-art overview of the best evidence non-invasive rehabilitation for CLBP is provided, except for pain neuroscience education and spinal manipulative therapy if combined with exercise therapy, with or without psychological therapy.