Journal ArticleDOI
Sleep disturbances and severe stress as glial activators: key targets for treating central sensitization in chronic pain patients?
Jo Nijs,Marco L. Loggia,Andrea Polli,Maarten Moens,Eva Huysmans,Lisa Goudman,Mira Meeus,Luc Vanderweeën,Kelly Ickmans,Daniel J. Clauw +9 more
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TLDR
This review focused on preclinical work and mostly on the neurobiochemistry studied in animals, with limited human studies available, to explore the mechanisms of sensitization of the central nervous system in chronic pain patients.Abstract:
Introduction: The mechanism of sensitization of the central nervous system partly explains the chronic pain experience in many patients, but the etiological mechanisms of this central nervous system dysfunction are poorly understood. Recently, an increasing number of studies suggest that aberrant glial activation takes part in the establishment and/or maintenance of central sensitization.Areas covered: This review focused on preclinical work and mostly on the neurobiochemistry studied in animals, with limited human studies available. Glial overactivation results in a low-grade neuroinflammatory state, characterized by high levels of BDNF, IL-1β, TNF-α, which in turn increases the excitability of the central nervous system neurons through mechanisms like long-term potentiation and increased synaptic efficiency. Aberrant glial activity in chronic pain might have been triggered by severe stress exposure, and/or sleeping disturbances, each of which are established initiating factors for chronic pain d...read more
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Sleep disturbances in chronic pain: Neurobiology, assessment, and treatment in physical therapist practice
Jo Nijs,Olivier Mairesse,Daniel Neu,Laurence Leysen,Lieven Danneels,Barbara Cagnie,Mira Meeus,Maarten Moens,Kelly Ickmans,Dorien Goubert +9 more
TL;DR: The current understanding of insomnia is applied to clinical practice, including assessment and conservative treatment of insomnia in people with chronic pain.
Journal ArticleDOI
Central sensitization in chronic pain and medically unexplained symptom research: A systematic review of definitions, operationalizations and measurement instruments
Carine den Boer,Linne Dries,Berend Terluin,Johannes C. van der Wouden,Annette H. Blankenstein,C. Paul van Wilgen,Peter Lucassen,Henriëtte E. van der Horst +7 more
TL;DR: There is consensus that hyperexcitability is the central mechanism of CS and operationalizations are based on this mechanism and additional components and there are many measurement instruments available, whose clinical value has still to be determined.
Journal ArticleDOI
Treatment of central sensitization in patients with chronic pain: time for change?
Jo Nijs,Laurence Leysen,Johan Vanlauwe,Tine Logghe,Kelly Ickmans,Andrea Polli,Anneleen Malfliet,Iris Coppieters,Iris Coppieters,Eva Huysmans +9 more
TL;DR: The treatment rationale based on the complex mechanisms underlying CS in patients having chronic pain is presented and emphasis is given to explaining the concept of CS when providing treatment, as well as why patients and clinicians should focus on long-term rather than short-term treatment effects.
Journal ArticleDOI
Neck pain: global epidemiology, trends and risk factors
Seyed Aria Nejadghaderi,Parastoo Amiri,Hojjat Pourfathi,Mostafa Araj-Khodaei,Mark J.M. Sullman,Ali-Asghar Kolahi,Saeid Safiri +6 more
TL;DR: In this article , a literature review describes the global epidemiology and trends associated with neck pain, before exploring the psychological and biological risk factors associated with the initiation and progression of neck pain.
Journal ArticleDOI
Nociplastic Pain Criteria or Recognition of Central Sensitization? Pain Phenotyping in the Past, Present and Future.
Jo Nijs,Jo Nijs,Astrid Lahousse,Astrid Lahousse,Eleni Kapreli,Paraskevi Bilika,İsmail Saraçoğlu,Anneleen Malfliet,Anneleen Malfliet,Iris Coppieters,Liesbet De Baets,Laurence Leysen,Eva Roose,Jacqui R Clark,Lennard Voogt,Eva Huysmans,Eva Huysmans +16 more
TL;DR: The International Association for the Study of Pain (IASP) released clinical criteria and a grading system for nociplastic pain affecting the musculoskeletal system as mentioned in this paper.
References
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Journal ArticleDOI
Central sensitization: implications for the diagnosis and treatment of pain.
TL;DR: Diagnostic criteria to establish the presence of central sensitization in patients will greatly assist the phenotyping of patients for choosing treatments that produce analgesia by normalizing hyperexcitable central neural activity.
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Chronic stress induces contrasting patterns of dendritic remodeling in hippocampal and amygdaloid neurons.
TL;DR: It is raised the possibility that certain forms of chronic stress, by affecting specific neuronal elements in the amygdala, may lead to behavioral manifestations of enhanced emotionality, and stress-induced structural plasticity in amygdala neurons may provide a candidate cellular substrate for affective disorders triggered by chronic stress.
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Central sensitization and LTP: do pain and memory share similar mechanisms?
TL;DR: Analysis of the molecular mechanisms underlying the generation and maintenance of central sensitization and LTP indicates that, although there are differences between the synaptic plasticity contributing to memory and pain, there are also striking similarities.
Journal ArticleDOI
Different immune cells mediate mechanical pain hypersensitivity in male and female mice
Robert E. Sorge,Josiane C.S. Mapplebeck,Sarah F. Rosen,Simon Beggs,Sarah Taves,Jessica K. Alexander,Loren J. Martin,Jean-Sebastien Austin,Susana G. Sotocinal,Di Chen,Mu Yang,Xiang Qun Shi,Hao Huang,Nicolas J. Pillon,Philip J. Bilan,Yu Shan Tu,Amira Klip,Ru-Rong Ji,Ji Zhang,Michael W. Salter,Jeffrey S. Mogil +20 more
TL;DR: It is found that microglia are not required for mechanical pain hypersensitivity in female mice; female mice achieved similar levels of pain hypers sensitivity using adaptive immune cells, likely T lymphocytes, suggesting that male mice cannot be used as proxies for females in pain research.