Eva Uzvolgyi

TL;DR: Investigation of the expression of human DNMT1, 3a and 3b found widespread, coordinate expression of all three transcripts in most normal tissues, and several novel alternatively spliced forms of DNMT3b, which may have altered enzymatic activity, were found to be expressed in a tissue-specific manner.

TL;DR: It is hypothesized that formation of the reactive organic intermediate dimethylarsinous acid (DMA(III) is involved in the induction of the cytotoxicity and regenerative hyperplasia of the urothelium which was inhibited by co-administration with DMPS.

TL;DR: The results show the existence of differential, tissue-dependent methylation at the EDNRB 5' region, suggest the exist of a spreading mechanism for de novo methylation, starting from methylation hotspots, and show that hypermethylation immediately 3' to a transcriptional start site does not prevent initiation.

TL;DR: A long-range physical map of the Usher type IIa critical region, using MluI, BssHII, NotI, EagI, and SacII, has been developed and analysis of newly positioned polymorphic markers in recombinant individuals in two Usher syndrometype IIa families has enabled us to identify DXS474 and AFM144XF2 as two flanking markers for the Ushers type IIA locus.

TL;DR: B6D2F1 mice are susceptible to the urothelial carcinogenic effects of BBN and develop frequent p53 mutations and chromosome 4 deletions.