J
Janos Sumegi
Researcher at University of Nebraska Medical Center
Publications - 29
Citations - 3584
Janos Sumegi is an academic researcher from University of Nebraska Medical Center. The author has contributed to research in topics: Gene & Gene mapping. The author has an hindex of 19, co-authored 28 publications receiving 3434 citations. Previous affiliations of Janos Sumegi include University of Nebraska–Lincoln & Translational Genomics Research Institute.
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Journal ArticleDOI
The human DNA methyltransferases (DNMTs) 1, 3a and 3b: coordinate mRNA expression in normal tissues and overexpression in tumors.
Keith D. Robertson,Eva Uzvolgyi,Gangning Liang,Cathy Talmadge,Janos Sumegi,Felicidad A. Gonzales,Peter A. Jones +6 more
TL;DR: Investigation of the expression of human DNMT1, 3a and 3b found widespread, coordinate expression of all three transcripts in most normal tissues, and several novel alternatively spliced forms of DNMT3b, which may have altered enzymatic activity, were found to be expressed in a tissue-specific manner.
Journal ArticleDOI
Host response to EBV infection in X-linked lymphoproliferative disease results from mutations in an SH2-domain encoding gene
Alison J. Coffey,Robert A. Brooksbank,Oliver Brandau,Toshitaka Oohashi,Gareth R. Howell,Jacqueline M. Bye,Anthony P. Cahn,Anthony P. Cahn,Jillian Durham,Paul Heath,Paul Wray,Rebecca Pavitt,Jane Wilkinson,Margaret A. Leversha,Elizabeth J. Huckle,Charles Shaw-Smith,Andrew Dunham,Susan Rhodes,Volker Schuster,Giovanni Porta,Luo Yin,Paola Serafini,Bakary S. Sylla,Massimo Zollo,Brunella Franco,Alessandra Bolino,Marco Seri,Arpad Lanyi,Jack R. Davis,David Webster,Ann Harris,Gilbert M. Lenoir,Genevieve de St Basile,Alison Jones,Bernd H. Behloradsky,Helene Achatz,Jan Murken,Reinhard Fässler,Janos Sumegi,Giovanni Romeo,M. Vaudin,Mark T. Ross,Alfons Meindl,David R. Bentley +43 more
TL;DR: A gene, SH2D1A, is identified that is mutated in XLP patients and encodes a novel protein composed of a single SH2 domain that is expressed in many tissues involved in the immune system.
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Mutation of a gene encoding a protein with extracellular matrix motifs in Usher syndrome type IIa
James D. Eudy,Michael D. Weston,Su Fang Yao,Denise M. Hoover,Heidi L. Rehm,Manling Ma-Edmonds,Denise Yan,Iqbal Ahmad,Jason J. Cheng,Carmen Ayuso,Cor W. R. J. Cremers,S. Davenport,Claes Möller,Catherine B. Talmadge,Kirk W. Beisel,Marta L. Tamayo,Cynthia C. Morton,Anand Swaroop,William J. Kimberling,Janos Sumegi +19 more
TL;DR: Three biologically important mutations in Usher syndrome type IIa patients were identified in a gene (USH2A) isolated from this critical region of human chromosome 1q41 that has laminin epidermal growth factor and fibronectin type III motifs.
Journal ArticleDOI
SAP couples Fyn to SLAM immune receptors.
Betty Liwah Chan,Arpad Lanyi,Arpad Lanyi,Hyun Kyu Song,Jan Griesbach,Maria Simarro-Grande,Florence Poy,Duncan Howie,Janos Sumegi,Cox Terhorst,Michael J. Eck +10 more
TL;DR: The crystal structure of a ternary SLAM–SAP–Fyn-SH3 complex reveals that SAP binds the FynT SH3 domain through a surface–surface interaction that does not involve canonical SH3 or SH2 binding interactions.
Journal ArticleDOI
Crystal structures of the XLP protein SAP reveal a class of SH2 domains with extended, phosphotyrosine-independent sequence recognition.
Florence Poy,Michael B. Yaffe,Joan Sayós,Kumkum Saxena,Massimo Morra,Janos Sumegi,Lewis C. Cantley,Lewis C. Cantley,Cox Terhorst,Michael J. Eck +9 more
TL;DR: Structures that show that SAP binds phosphorylated and nonphosphorylated SLAM peptides in a similar mode, with the tyrosine or phosphotyrosine residue inserted into the phosphotYrosine-binding pocket are described.