E
Evan Lemire
Researcher at Broad Institute
Publications - 9
Citations - 384
Evan Lemire is an academic researcher from Broad Institute. The author has contributed to research in topics: Medicine & Drug repositioning. The author has an hindex of 2, co-authored 2 publications receiving 151 citations.
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Journal ArticleDOI
Discovering the anti-cancer potential of non-oncology drugs by systematic viability profiling.
Steven M. Corsello,Steven M. Corsello,Rohith T. Nagari,Ryan Spangler,Jordan Rossen,Mustafa Kocak,Jordan Bryan,Jordan Bryan,Ranad Humeidi,David Peck,Xiaoyun Wu,Anna Tang,Vickie M. Wang,Sam Bender,Evan Lemire,Rajiv Narayan,Philip Montgomery,Uri Ben-David,Uri Ben-David,Colin W. Garvie,Yii-Der Ida Chen,Matthew G. Rees,Nicholas J. Lyons,James M. McFarland,Bang Wong,Li Wang,Nancy Dumont,Patrick O'Hearn,Eric Stefan,Eric Stefan,John G. Doench,Caitlin N. Harrington,Heidi Greulich,Matthew Meyerson,Matthew Meyerson,Francisca Vazquez,Ayshwarya Subramanian,Jennifer Roth,Joshua Bittker,Joshua Bittker,Jesse S. Boehm,Christopher C. Mader,Aviad Tsherniak,Todd R. Golub +43 more
TL;DR: An unexpectedly large number of non-oncology drugs selectively inhibited subsets of cancer cell lines in a manner predictable from the cell lines' molecular features.
Posted ContentDOI
Non-oncology drugs are a source of previously unappreciated anti-cancer activity
Steven M. Corsello,Steven M. Corsello,Rohith T. Nagari,Ryan Spangler,Jordan Rossen,Mustafa Kocak,Jordan Bryan,Ranad Humeidi,David Peck,Xiaoyun Wu,Anna Tang,Vickie M. Wang,Sam Bender,Evan Lemire,Rajiv Narayan,Philip Montgomery,Uri Ben-David,Yii-Der Ida Chen,Matthew G. Rees,Nicholas J. Lyons,James M. McFarland,Bang Wong,Li Wang,Nancy Dumont,Patrick O'Hearn,Eric Stefan,John G. Doench,Heidi Greulich,Matthew Meyerson,Matthew Meyerson,Francisca Vazquez,Ayshwarya Subramanian,Jennifer Roth,Joshua Bittker,Jesse S. Boehm,Christopher C. Mader,Aviad Tsherniak,Todd R. Golub +37 more
TL;DR: The results illustrate the potential of the PRISM drug repurposing resource as a starting point for new oncology therapeutic development and relative barcode abundance following treatment thus reflects cell line viability.
Journal ArticleDOI
Unequal Housing Conditions And Code Enforcement Contribute To Asthma Disparities In Boston, Massachusetts.
TL;DR: Evidence is found that in Boston, despite several healthy housing initiatives, current regulatory systems are insufficient to address disparities in access to healthy housing and to reduce disparities in asthma burden, stronger inspectional standards and further enforcement policies to increase landlords' accountability and support tenants' rights to have repairs made are essential.
Journal ArticleDOI
Mapping emergency department asthma visits to identify poor-quality housing in New Haven, CT, USA: a retrospective cohort study
Elizabeth A. Samuels,J. Richard Taylor,Akshay Pendyal,Abbas Shojaee,Anne Mainardi,Evan Lemire,Arjun K. Venkatesh,Steven L. Bernstein,Adam L. Haber +8 more
TL;DR: A retrospective cohort study of children and adults living in and around New Haven, CT, USA, who were seen for asthma in an urban, tertiary emergency department to evaluate whether emergency department visits for asthma can be used to identify poor-quality housing to support proactive and early intervention.
Posted ContentDOI
TRPM5+ microvillous tuft cells regulate neuroepithelial intrinsic olfactory stem cell proliferation
Saltanat Ualiyeva,Evan Lemire,Cai Hui. Wong,Amelia A. Boyd,Evelyn C. Aviles,D. Minichetti,A Perniß,Alice Z. Maxfield,Rachel E. Roditi,Ichiro Matsumoto,Nora A. Barrett,Kathleen M. Buchheit,Tanya M. Laidlaw,Joshua A. Boyce,Lora G. Bankova,Adam L. Haber +15 more
TL;DR: In this paper , the authors identify the enigmatic TRPM5+ olfactory microvillous cells as tuft cells, and show their functional role as regulators of Olfactory stem cell proliferation in response to environmental signals.