A
Anna Tang
Researcher at Broad Institute
Publications - 13
Citations - 2636
Anna Tang is an academic researcher from Broad Institute. The author has contributed to research in topics: Drug repositioning & Epigenome. The author has an hindex of 9, co-authored 12 publications receiving 1828 citations. Previous affiliations of Anna Tang include Brigham and Women's Hospital.
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Journal ArticleDOI
Alzheimer's disease: early alterations in brain DNA methylation at ANK1, BIN1, RHBDF2 and other loci.
Philip L. De Jager,Gyan Srivastava,Katie Lunnon,Jeremy D. Burgess,Leonard C. Schalkwyk,Lei Yu,Matthew L. Eaton,Brendan T. Keenan,Jason Ernst,Cristin McCabe,Anna Tang,Towfique Raj,Joseph M. Replogle,Wendy Brodeur,Stacey Gabriel,High Seng Chai,Curtis S. Younkin,Steven G. Younkin,Fanggeng Zou,Moshe Szyf,Charles B. Epstein,Julie A. Schneider,Bradley E. Bernstein,Alexander Meissner,Nilufer Ertekin-Taner,Lori B. Chibnik,Manolis Kellis,Jonathan Mill,David A. Bennett +28 more
TL;DR: The analyses suggest that DNA methylation changes may have a role in the onset of AD given that they were observed in presymptomatic subjects and that six of the validated genes connect to a known AD susceptibility gene network.
Journal ArticleDOI
CD33 Alzheimer’s disease locus: Altered monocyte function and amyloid biology
Elizabeth M. Bradshaw,Lori B. Chibnik,Brendan T. Keenan,Brendan T. Keenan,Linda Ottoboni,Towfique Raj,Anna Tang,Anna Tang,Laura Rosenkrantz,Laura Rosenkrantz,Selina Imboywa,Selina Imboywa,Michelle Lee,Alina Von Korff,Martha Clare Morris,Denis A. Evans,Keith A. Johnson,Reisa A. Sperling,Julie A. Schneider,David A. Bennett,Philip L. De Jager,Philip L. De Jager +21 more
TL;DR: In the authors' functional dissection of the CD33 Alzheimer's disease susceptibility locus, it was found that the rs3865444C risk allele was associated with greater cell surface expression of CD33 in the monocytes of young and older individuals.
Journal ArticleDOI
Discovering the anti-cancer potential of non-oncology drugs by systematic viability profiling.
Steven M. Corsello,Steven M. Corsello,Rohith T. Nagari,Ryan Spangler,Jordan Rossen,Mustafa Kocak,Jordan Bryan,Jordan Bryan,Ranad Humeidi,David Peck,Xiaoyun Wu,Anna Tang,Vickie M. Wang,Sam Bender,Evan Lemire,Rajiv Narayan,Philip Montgomery,Uri Ben-David,Uri Ben-David,Colin W. Garvie,Yii-Der Ida Chen,Matthew G. Rees,Nicholas J. Lyons,James M. McFarland,Bang Wong,Li Wang,Nancy Dumont,Patrick O'Hearn,Eric Stefan,Eric Stefan,John G. Doench,Caitlin N. Harrington,Heidi Greulich,Matthew Meyerson,Matthew Meyerson,Francisca Vazquez,Ayshwarya Subramanian,Jennifer Roth,Joshua Bittker,Joshua Bittker,Jesse S. Boehm,Christopher C. Mader,Aviad Tsherniak,Todd R. Golub +43 more
TL;DR: An unexpectedly large number of non-oncology drugs selectively inhibited subsets of cancer cell lines in a manner predictable from the cell lines' molecular features.
Alzheimer's disease: early alterations in brain DNA methylation at ANK1, BIN1, RHBDF2 and other loci
Gyan Srivastava,Katie Lunnon,Jeremy D. Burgess,Lei Yu,Jason Ernst,Cristin McCabe,Anna Tang,Towfique Raj,Joseph M. Replogle,Wendy Brodeur,Stacey Gabriel,Curtis S. Younkin,Fanggeng Zou,Moshe Szyf,Alexander Meissner,Nilufer Ertekin-Taner,Manolis Kellis,Jonathan Mill,Philip L. De Jager,Leonard C. Schalkwyk,Matthew L. Eaton,Matthew L. Eaton,Brendan T. Keenan,High Seng Chai,Steven G. Younkin,Charles B. Epstein,Julie A. Schneider,Bradley E. Bernstein,Lori B. Chibnik,David A. Bennett +29 more
TL;DR: The analyses suggest that DNA methylation changes may have a role in the onset of AD since (1) they are seen in presymptomatic subjects and (2) six of the validated genes connect to a known AD susceptibility gene network.
Journal ArticleDOI
A multi-omic atlas of the human frontal cortex for aging and Alzheimer’s disease research
Phillip L De Jager,Phillip L De Jager,Yiyi Ma,Cristin McCabe,Jishu Xu,Badri N. Vardarajan,Daniel Felsky,Daniel Felsky,Hans-Ulrich Klein,Hans-Ulrich Klein,Charles C. White,Mette A. Peters,Ben Lodgson,Parham Nejad,Anna Tang,Lara M. Mangravite,Lei Yu,Chris Gaiteri,Sara Mostafavi,Julie A. Schneider,David A. Bennett +20 more
TL;DR: The systematic profiling of the dorsolateral prefrontal cortex obtained from a subset of autopsied individuals enrolled in the Religious Orders Study or the Rush Memory and Aging Project, which are jointly designed prospective studies of aging and dementia with detailed, longitudinal cognitive phenotyping during life and a quantitative, structured neuropathologic examination after death, is initiated.