A
Adam L. Haber
Researcher at Broad Institute
Publications - 31
Citations - 4361
Adam L. Haber is an academic researcher from Broad Institute. The author has contributed to research in topics: Immune system & Cell type. The author has an hindex of 14, co-authored 25 publications receiving 2820 citations. Previous affiliations of Adam L. Haber include University of New South Wales & Massachusetts Institute of Technology.
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Journal ArticleDOI
A single-cell survey of the small intestinal epithelium
Adam L. Haber,Moshe Biton,Moshe Biton,Noga Rogel,Rebecca H. Herbst,Rebecca H. Herbst,Karthik Shekhar,Christopher Smillie,Grace Burgin,Toni Delorey,Toni Delorey,Michael R. Howitt,Yarden Katz,Itay Tirosh,Semir Beyaz,Danielle Dionne,Mei Zhang,Raktima Raychowdhury,Wendy S. Garrett,Wendy S. Garrett,Orit Rozenblatt-Rosen,Hai Ning Shi,Ömer H. Yilmaz,Ömer H. Yilmaz,Ramnik J. Xavier,Ramnik J. Xavier,Aviv Regev +26 more
TL;DR: This paper reported profiling of 53,193 individual epithelial cells from the small intestine and organoids of mice, which enabled the identification and characterization of previously unknown subtypes of intestinal epithelial cell and their gene signatures.
Journal ArticleDOI
A revised airway epithelial hierarchy includes CFTR-expressing ionocytes
Daniel T. Montoro,Adam L. Haber,Moshe Biton,Moshe Biton,Vladimir Vinarsky,Brian M. Lin,Susan E. Birket,Feng Yuan,Sijia Chen,Hui Min Leung,Jorge Villoria,Noga Rogel,Grace Burgin,Alexander M. Tsankov,Avinash Waghray,Michal Slyper,Julia Waldman,Lan Nguyen,Danielle Dionne,Orit Rozenblatt-Rosen,Purushothama Rao Tata,Hongmei Mou,Manjunatha Shivaraju,Hermann Bihler,Martin Mense,Guillermo J. Tearney,Steven M. Rowe,John F. Engelhardt,Aviv Regev,Aviv Regev,Jayaraj Rajagopal +30 more
TL;DR: ‘pulse-seq’ is developed, combining scRNA-seq and lineage tracing, to show that tuft, neuroendocrine and ionocyte cells are continually and directly replenished by basal progenitor cells, establishing a new cellular narrative for airways disease.
Journal ArticleDOI
Intra- and Inter-cellular Rewiring of the Human Colon during Ulcerative Colitis
Christopher Smillie,Moshe Biton,Jose Ordovas-Montanes,Keri M. Sullivan,Grace Burgin,Daniel B. Graham,Rebecca H. Herbst,Rebecca H. Herbst,Noga Rogel,Michal Slyper,Julia Waldman,Malika Sud,Elizabeth Andrews,Gabriella Velonias,Adam L. Haber,Karthik A. Jagadeesh,Sanja Vickovic,Junmei Yao,Christine Stevens,Danielle Dionne,Lan T. Nguyen,Alexandra-Chloé Villani,Matan Hofree,Elizabeth A. Creasey,Hailiang Huang,Orit Rozenblatt-Rosen,John J. Garber,Hamed Khalili,A. Nicole Desch,Mark J. Daly,Mark J. Daly,Ashwin N. Ananthakrishnan,Alex K. Shalek,Ramnik J. Xavier,Aviv Regev,Aviv Regev +35 more
TL;DR: An atlas of 366,650 cells from the colon mucosa of 18 UC patients and 12 healthy individuals is generated, revealing 51 epithelial, stromal, and immune cell subsets, including BEST4+ enterocytes, microfold-like cells, and IL13RA2+IL11+ inflammatory fibroblasts, which are associated with resistance to anti-TNF treatment.
A single-cell survey of the small intestinal epithelium
Adam L. Haber,Moshe Biton,Moshe Biton,Noga Rogel,Rebecca H. Herbst,Rebecca H. Herbst,Karthik Shekhar,Christopher Smillie,Grace Burgin,Toni Delorey,Toni Delorey,Michael R. Howitt,Yarden Katz,Itay Tirosh,Semir Beyaz,Danielle Dionne,Mei Zhang,Raktima Raychowdhury,Wendy S. Garrett,Wendy S. Garrett,Orit Rozenblatt-Rosen,Hai Ning Shi,Ömer H. Yilmaz,Ömer H. Yilmaz,Ramnik J. Xavier,Ramnik J. Xavier,Aviv Regev +26 more
TL;DR: The authors reported profiling of 53,193 individual epithelial cells from the small intestine and organoids of mice, which enabled the identification and characterization of previously unknown subtypes of intestinal epithelial cell and their gene signatures.
Journal ArticleDOI
T Helper Cell Cytokines Modulate Intestinal Stem Cell Renewal and Differentiation.
Moshe Biton,Moshe Biton,Adam L. Haber,Noga Rogel,Grace Burgin,Semir Beyaz,Semir Beyaz,Semir Beyaz,Alexandra Schnell,Orr Ashenberg,Chien-wen Su,Christopher Smillie,Karthik Shekhar,Zuojia Chen,Chuan Wu,Jose Ordovas-Montanes,David Alvarez,Rebecca H. Herbst,Rebecca H. Herbst,Mei Zhang,Itay Tirosh,Itay Tirosh,Danielle Dionne,Lan T. Nguyen,Michael E. Xifaras,Alex K. Shalek,Ulrich H. von Andrian,Daniel B. Graham,Orit Rozenblatt-Rosen,Hai Ning Shi,Vijay K. Kuchroo,Vijay K. Kuchroo,Ömer H. Yilmaz,Ömer H. Yilmaz,Ömer H. Yilmaz,Aviv Regev,Aviv Regev,Ramnik J. Xavier +37 more
TL;DR: It is shown that MHCII+ Lgr5+ ISCs are non-conventional antigen-presenting cells in co-cultures with CD4+ T helper (Th) cells, which orchestrate tissue-wide responses to external signals.