R
Rohith T. Nagari
Researcher at Broad Institute
Publications - 4
Citations - 386
Rohith T. Nagari is an academic researcher from Broad Institute. The author has contributed to research in topics: Drug repositioning & Medicine. The author has an hindex of 2, co-authored 2 publications receiving 151 citations.
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Journal ArticleDOI
Discovering the anti-cancer potential of non-oncology drugs by systematic viability profiling.
Steven M. Corsello,Steven M. Corsello,Rohith T. Nagari,Ryan Spangler,Jordan Rossen,Mustafa Kocak,Jordan Bryan,Jordan Bryan,Ranad Humeidi,David Peck,Xiaoyun Wu,Anna Tang,Vickie M. Wang,Sam Bender,Evan Lemire,Rajiv Narayan,Philip Montgomery,Uri Ben-David,Uri Ben-David,Colin W. Garvie,Yii-Der Ida Chen,Matthew G. Rees,Nicholas J. Lyons,James M. McFarland,Bang Wong,Li Wang,Nancy Dumont,Patrick O'Hearn,Eric Stefan,Eric Stefan,John G. Doench,Caitlin N. Harrington,Heidi Greulich,Matthew Meyerson,Matthew Meyerson,Francisca Vazquez,Ayshwarya Subramanian,Jennifer Roth,Joshua Bittker,Joshua Bittker,Jesse S. Boehm,Christopher C. Mader,Aviad Tsherniak,Todd R. Golub +43 more
TL;DR: An unexpectedly large number of non-oncology drugs selectively inhibited subsets of cancer cell lines in a manner predictable from the cell lines' molecular features.
Posted ContentDOI
Non-oncology drugs are a source of previously unappreciated anti-cancer activity
Steven M. Corsello,Steven M. Corsello,Rohith T. Nagari,Ryan Spangler,Jordan Rossen,Mustafa Kocak,Jordan Bryan,Ranad Humeidi,David Peck,Xiaoyun Wu,Anna Tang,Vickie M. Wang,Sam Bender,Evan Lemire,Rajiv Narayan,Philip Montgomery,Uri Ben-David,Yii-Der Ida Chen,Matthew G. Rees,Nicholas J. Lyons,James M. McFarland,Bang Wong,Li Wang,Nancy Dumont,Patrick O'Hearn,Eric Stefan,John G. Doench,Heidi Greulich,Matthew Meyerson,Matthew Meyerson,Francisca Vazquez,Ayshwarya Subramanian,Jennifer Roth,Joshua Bittker,Jesse S. Boehm,Christopher C. Mader,Aviad Tsherniak,Todd R. Golub +37 more
TL;DR: The results illustrate the potential of the PRISM drug repurposing resource as a starting point for new oncology therapeutic development and relative barcode abundance following treatment thus reflects cell line viability.
Journal ArticleDOI
Hepatic nonvesicular cholesterol transport is critical for systemic lipid homeostasis
Xu Xiao,John P. Kennelly,Alessandra Ferrari,Bethan L. Clifford,Emily Whang,Yajing Gao,Kevin Qian,Jaspreet S. Sandhu,Kelsey E Jarrett,Madelaine C. Brearley-Sholto,Alexander Nguyen,Rohith T. Nagari,Minsub S Lee,Sicheng Zhang,Thomas A. Weston,Stephen G. Young,Steven J. Bensinger,Claudio J. Villanueva,Thomas Q. de Aguiar Vallim,Peter Tontonoz +19 more
Journal ArticleDOI
Brap regulates liver morphology and hepatocyte turnover via modulation of the Hippo pathway
Christina Priest,Rohith T. Nagari,Lara Bideyan,Stephen Lee,Alexander Nguyen,Xu Xiao,Peter Tontonoz +6 more
TL;DR: It is shown that BRAP, a ubiquitin ligase of poorly understood function, is required for maintenance of proper liver morphology and has implications for liver disease.