E
Evan M. Zhao
Researcher at Princeton University
Publications - 19
Citations - 945
Evan M. Zhao is an academic researcher from Princeton University. The author has contributed to research in topics: Metabolic engineering & Transgene. The author has an hindex of 8, co-authored 19 publications receiving 376 citations. Previous affiliations of Evan M. Zhao include Wyss Institute for Biologically Inspired Engineering.
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Journal ArticleDOI
Optogenetic regulation of engineered cellular metabolism for microbial chemical production
Evan M. Zhao,Yanfei Zhang,Justin Mehl,Helen Park,Makoto A. Lalwani,Jared E. Toettcher,José L. Avalos +6 more
TL;DR: It is shown that light-controlled transcription can be used to enhance the biosynthesis of valuable products in engineered Saccharomyces cerevisiae and makes a compelling case for the application of optogenetics to metabolic engineering for the production of valuable Products.
Journal ArticleDOI
Wearable materials with embedded synthetic biology sensors for biomolecule detection.
Peter Q. Nguyen,Peter Q. Nguyen,Luis R. Soenksen,Luis R. Soenksen,Nina M. Donghia,Nicolaas M. Angenent-Mari,Nicolaas M. Angenent-Mari,Helena de Puig,Helena de Puig,Ally Huang,Ally Huang,Rose A. Lee,Shimyn Slomovic,Tommaso Galbersanini,Geoffrey Lansberry,Hani M. Sallum,Evan M. Zhao,James B. Niemi,James J. Collins +18 more
TL;DR: In this article, a face mask with a lyophilized CRISPR sensor for wearable, noninvasive detection of SARS-CoV-2 at room temperature within 90 min, requiring no user intervention other than the press of a button.
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Light-based control of metabolic flux through assembly of synthetic organelles.
Evan M. Zhao,Nathan Suek,Maxwell Z. Wilson,Elliot Dine,Nicole L. Pannucci,Zemer Gitai,José L. Avalos,Jared E. Toettcher +7 more
TL;DR: It is reported that optogenetic control can be used to extend compartmentalization and dynamic control to engineered metabolisms in yeast and enhances product formation and specificity during deoxyviolacein biosynthesis by decreasing concentrations of intermediate metabolites and reducing flux through competing pathways.
Journal ArticleDOI
Optogenetic control of protein binding using light-switchable nanobodies.
Agnieszka A. Gil,César Carrasco-López,Liyuan Zhu,Evan M. Zhao,Pavithran T. Ravindran,Maxwell Z. Wilson,Alexander G. Goglia,José L. Avalos,Jared E. Toettcher +8 more
TL;DR: The development of opto-nanobodies (OptoNBs), a versatile class of chimeric photoswitchable proteins whose binding to proteins of interest can be enhanced or inhibited upon blue light illumination, represents a step towards programmable photos witchable regulation of a wide variety of target proteins.
Journal ArticleDOI
Current and future modalities of dynamic control in metabolic engineering.
TL;DR: The potential of integrating biosensors and computer-assisted feedback control as a promising future modality of dynamic control in metabolic engineering is explored.