C
César Carrasco-López
Researcher at Princeton University
Publications - 35
Citations - 1232
César Carrasco-López is an academic researcher from Princeton University. The author has contributed to research in topics: Peptidoglycan & Lipase. The author has an hindex of 14, co-authored 33 publications receiving 902 citations. Previous affiliations of César Carrasco-López include New York University Abu Dhabi & University of Los Andes.
Papers
More filters
Journal ArticleDOI
How allosteric control of Staphylococcus aureus penicillin binding protein 2a enables methicillin resistance and physiological function
Lisandro H. Otero,Alzoray Rojas-Altuve,Leticia I. Llarrull,César Carrasco-López,Malika Kumarasiri,Elena Lastochkin,Jennifer Fishovitz,Matthew Dawley,Dusan Hesek,Mijoon Lee,Jarrod W. Johnson,Jed F. Fisher,Mayland Chang,Shahriar Mobashery,Juan A. Hermoso +14 more
TL;DR: The identification of an allosteric binding domain—a remarkable 60 Å distant from the dd-transpeptidase active site—discovered by crystallographic analysis of a soluble construct of PBP2a opens an unprecedented realm for β-lactam antibiotic structure-based design.
Journal ArticleDOI
Activation of Bacterial Thermoalkalophilic Lipases Is Spurred by Dramatic Structural Rearrangements
César Carrasco-López,César A. Godoy,Blanca de las Rivas,Gloria Fernández-Lorente,Jose M. Palomo,Jose M. Guisan,Roberto Fernandez-Lafuente,Martín Martínez-Ripoll,Juan A. Hermoso +8 more
TL;DR: The combination of structural and biochemical studies indicate that the lid opening is not mediated by temperature but triggered by interaction with lipid substrate, and the first structure of a member of the lipase family I.5 showing an open configuration is reported.
Journal ArticleDOI
Enolase as a plasminogen binding protein in Leishmania mexicana
Gilmer Vanegas,Wilfredo Quiñones,César Carrasco-López,Juan Luis Concepción,Fernando Albericio,Luisana Avilan +5 more
TL;DR: It is shown that the purified recombinant enolase has plasminogen binding activity indicating that, at the surface of the parasite, the protein may function as one of the plAsminogen receptors.
Journal ArticleDOI
Optogenetic control of protein binding using light-switchable nanobodies.
Agnieszka A. Gil,César Carrasco-López,Liyuan Zhu,Evan M. Zhao,Pavithran T. Ravindran,Maxwell Z. Wilson,Alexander G. Goglia,José L. Avalos,Jared E. Toettcher +8 more
TL;DR: The development of opto-nanobodies (OptoNBs), a versatile class of chimeric photoswitchable proteins whose binding to proteins of interest can be enhanced or inhibited upon blue light illumination, represents a step towards programmable photos witchable regulation of a wide variety of target proteins.
Journal ArticleDOI
Disruption of allosteric response as an unprecedented mechanism of resistance to antibiotics.
Jennifer Fishovitz,Alzoray Rojas-Altuve,Lisandro H. Otero,Matthew Dawley,César Carrasco-López,Mayland Chang,Juan A. Hermoso,Shahriar Mobashery +7 more
TL;DR: Ceftaroline is able to inhibit penicillin-binding protein 2a (PBP2a) by triggering an allosteric conformational change that leads to the opening of the active site, an event that impairs cell-wall biosynthesis and leads to bacterial death.