Evelyn Lau

TL;DR: This work mapped interindividual variation in gene expression as a quantitative trait, defining expression quantitative trait loci (eQTLs) and found trans associations to the major histocompatibility complex are dependent on context, paralleling the expression of class II genes.

TL;DR: A broader role for CIITA beyond the MHC involving immune-related genes is indicated and new insights into allele-specific regulation ofCIITA informative for understanding gene function and disease are provided.

TL;DR: It is shown that allelic variation at rs6897932, an autoimmune GWAS risk allele at IL7R, regulates surface and soluble IL-7R in stimulated monocytes, indicating a function of monocytes in IL- 7-related autoimmunity.

TL;DR: The trial demonstrates the feasibility of applying functional genomic and genetic approaches in randomized trials to assess molecular and individual level responses and differs from many previous studies and does not support a strong effect of vitamin D on long-term transcriptomic changes in blood or on plasma cytokine levels.

TL;DR: In this article, an expression quantitative trait locus (eQTL) at rs6897932, associated with susceptibility to Multiple Sclerosis, Ankylosing Spondylitis and Primary Biliary Cirrhosis, was found to be the key determinant of monocyte IL7R surface expression.