E
Evelyn Nieves
Researcher at University of Michigan
Publications - 16
Citations - 906
Evelyn Nieves is an academic researcher from University of Michigan. The author has contributed to research in topics: Graft-versus-host disease & Antigen-presenting cell. The author has an hindex of 13, co-authored 16 publications receiving 862 citations. Previous affiliations of Evelyn Nieves include University of Illinois at Urbana–Champaign.
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Journal ArticleDOI
Interleukin-6 Modulates Graft-versus-Host Responses after Experimental Allogeneic Bone Marrow Transplantation
Isao Tawara,Motoko Koyama,Chen Liu,Tomomi Toubai,Dafydd G. Thomas,Rebecca Evers,Peter Chockley,Evelyn Nieves,Yaping Sun,Kathleen P. Lowler,Chelsea Malter,Norihiro Nishimoto,Geoffrey R. Hill,Pavan Reddy +13 more
TL;DR: Blockade of IL-6 with anti–IL-6R mAb therapy may be testable in clinical trials as an adjunct to prevent GVHD in BMT patients without a significant loss of GVT.
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Targeting of microRNA-142-3p in dendritic cells regulates endotoxin-induced mortality
Yaping Sun,Sooryanarayana Varambally,Christopher G. Maher,Qi Cao,Peter Chockley,Tomomi Toubai,Chelsea Malter,Evelyn Nieves,Isao Tawara,Yongqing Wang,Peter A. Ward,Arul M. Chinnaiyan,Pavan Reddy +12 more
TL;DR: A critical role for miR-142-3p in regulating DC responses to LPS is demonstrated and proof of concept for targeting miRs as a novel strategy for treatment of endotoxin-induced mortality is provided.
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Alpha-1-antitrypsin monotherapy reduces graft-versus-host disease after experimental allogeneic bone marrow transplantation.
Isao Tawara,Yaping Sun,Eli C. Lewis,Tomomi Toubai,Rebecca Evers,Evelyn Nieves,Tania Azam,Charles A. Dinarello,Pavan Reddy +8 more
TL;DR: Administration of AAT early after BMT decreased mortality in three models of GvHD and reduced serum levels of proinflammatory cytokines in the allogeneic recipients compared with vehicle (albumin) treated animals, suggesting that AAT represents a novel unique and viable strategy to mitigate clinical Gv HD.
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Induction of acute GVHD by sex-mismatched H-Y antigens in the absence of functional radiosensitive host hematopoietic–derived antigen-presenting cells
Tomomi Toubai,Isao Tawara,Yaping Sun,Chen Liu,Evelyn Nieves,Rebecca Evers,Thea M. Friedman,Robert Korngold,Pavan Reddy +8 more
TL;DR: The data suggest that infusion of sufficient numbers of alloreactive donor T cells will induce GVHD in the absence of radiosensitive host hematopoietic-derived APCs.
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Inhibition of histone methylation arrests ongoing graft-versus-host disease in mice by selectively inducing apoptosis of alloreactive effector T cells
Shan He,Jina Wang,Koji Kato,Fang Xie,Sooryanarayana Varambally,Shin Mineishi,Rork Kuick,Kazuhiro Mochizuki,Yongnian Liu,Evelyn Nieves,Ram Shankar Mani,Arul M. Chinnaiyan,Victor E. Marquez,Yi Zhang +13 more
TL;DR: In vivo administration of the histone methylation inhibitor 3-deazaneplanocin A (DZNep) arrests ongoing GVHD in mice after allogeneic BM transplantation and preserves the antileukemia activity of donor T cells and did not impair the recovery of hematopoiesis and lymphocytes, leading to significantly improved survival of recipients after allogenicic BM transplation.