E
Evgeny K. Apartsin
Researcher at Novosibirsk State University
Publications - 37
Citations - 473
Evgeny K. Apartsin is an academic researcher from Novosibirsk State University. The author has contributed to research in topics: Dendrimer & Chemistry. The author has an hindex of 9, co-authored 23 publications receiving 264 citations. Previous affiliations of Evgeny K. Apartsin include Russian Academy of Sciences & Centre national de la recherche scientifique.
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Journal ArticleDOI
Dendrimers Show Promise for siRNA and microRNA Therapeutics
Volha Dzmitruk,Evgeny K. Apartsin,Aliaksei Ihnatsyeu-Kachan,Viktar Abashkin,Dzmitry Shcharbin,Maria Bryszewska +5 more
TL;DR: This review summarizes the latest experimental data and trends in the medical application of various types of dendrimer-based nanoconstructions as delivery systems for short small interfering RNAs and microRNAs at the cell and organism levels.
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Anticancer siRNA cocktails as a novel tool to treat cancer cells. Part (A). Mechanisms of interaction.
Maksim Ionov,Joanna Lazniewska,Volha Dzmitruk,Inessa Halets,Svetlana Loznikova,D. S. Novopashina,Evgeny K. Apartsin,Olga A. Krasheninina,Alya G. Venyaminova,Katarzyna Milowska,Olga Nowacka,Rafael Gomez-Ramirez,Francisco Javier de la Mata,Jean-Pierre Majoral,Dzmitry Shcharbin,Maria Bryszewska +15 more
TL;DR: The results indicate that siRNAs form complexes with all the dendrimers tested and that Oligoribonucleotide duplexes can be released from dendriplexes after heparin treatment and the structure of siRNA is maintained in the case of PAMAM or carbosilane d endrimers.
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Recent Advances in Nucleic Acid Targeting Probes and Supramolecular Constructs Based on Pyrene-Modified Oligonucleotides.
TL;DR: The recent advances in the use of pyrene-modified oligonucleotides as a platform for functional nucleic acid-based constructs are summarized and special attention is paid to the influence of the design ofPyrene- modified oligon nucleotides on their properties, i.e., the structure-function relationships.
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Multi-Target Inhibition of Cancer Cell Growth by SiRNA Cocktails and 5-Fluorouracil Using Effective Piperidine-Terminated Phosphorus Dendrimers
Aliaksei Ihnatsyeu-Kachan,Volha Dzmitruk,Evgeny K. Apartsin,Olga A. Krasheninina,Maksim Ionov,Svetlana Loznikova,Alya G. Venyaminova,Katarzyna Milowska,Dzmitry Shcharbin,Serge Mignani,María Ángeles Muñoz-Fernández,Jean-Pierre Majoral,Maria Bryszewska +12 more
TL;DR: The effectiveness of combined multi-target siRNA anticancer approach is demonstrated and a new highly effective serum stable nanomaterial vehicle for gene-based drugs is described.
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Topological aspects of the design of nanocarriers for therapeutic peptides and proteins
TL;DR: Several topological groups used for the design of nanoformulations for peptide and protein delivery are discussed: modification of polypeptide chains by host-guest interactions; packaging of proteins and peptides into liposomes; complexation and conjugation with dendrimers.