E
Evi Lippens
Researcher at Charité
Publications - 29
Citations - 2838
Evi Lippens is an academic researcher from Charité. The author has contributed to research in topics: Self-healing hydrogels & Bone regeneration. The author has an hindex of 17, co-authored 29 publications receiving 2200 citations. Previous affiliations of Evi Lippens include Ghent University & Wyss Institute for Biologically Inspired Engineering.
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Journal ArticleDOI
Hydrogels with tunable stress relaxation regulate stem cell fate and activity
Ovijit Chaudhuri,Ovijit Chaudhuri,Ovijit Chaudhuri,Luo Gu,Luo Gu,Darinka D. Klumpers,Darinka D. Klumpers,Darinka D. Klumpers,Max Darnell,Max Darnell,Sidi A. Bencherif,Sidi A. Bencherif,James C. Weaver,Nathaniel Huebsch,Hong-pyo Lee,Evi Lippens,Evi Lippens,Georg N. Duda,David J. Mooney,David J. Mooney +19 more
TL;DR: It is found that cell spreading, proliferation, and osteogenic differentiation of mesenchymal stem cells (MSCs) are all enhanced in cells cultured in gels with faster relaxation, highlighting stress relaxation as a key characteristic of cell-ECM interactions and as an important design parameter of biomaterials for cell culture.
Journal ArticleDOI
Matrix elasticity of void-forming hydrogels controls transplanted-stem-cell-mediated bone formation
Nathaniel Huebsch,Evi Lippens,Evi Lippens,Kangwon Lee,Kangwon Lee,Kangwon Lee,Manav Mehta,Sandeep T. Koshy,Sandeep T. Koshy,Sandeep T. Koshy,Max Darnell,Max Darnell,Rajiv Desai,Rajiv Desai,Christopher M. Madl,Maria M. Xu,Xuanhe Zhao,Xuanhe Zhao,Ovijit Chaudhuri,Ovijit Chaudhuri,Ovijit Chaudhuri,Catia S. Verbeke,Catia S. Verbeke,Woo Seob Kim,Woo Seob Kim,Woo Seob Kim,Karen Alim,Akiko Mammoto,Donald E. Ingber,Donald E. Ingber,Donald E. Ingber,Georg N. Duda,David J. Mooney,David J. Mooney +33 more
TL;DR: In this paper, a void-forming hydrogel was used to control mesenchymal stem cell osteogenesis and cell deployment in vitro and in vivo, respectively, by modifying the hydrogels' elastic modulus or its chemistry.
Matrix elasticity of void-forming hydrogels controls transplanted-stem-cell-mediated bone formation
Evi Lippens,Kangwon Lee,Manav Mehta,Sandeep T. Koshy,Max Darnell,Rajiv Desai,Christopher M. Madl,Maria M. Xu,Xuanhe Zhao,Ovijit Chaudhuri,Catia S. Verbeke,Woo Seob Kim,Karen Alim,Akiko Mammoto,Donald E. Ingber,Georg N. Duda,David J. Mooney,Nathaniel Huebsch +17 more
TL;DR: By developing injectable, void-forming hydrogels that decouple pore formation from elasticity, this work shows that mesenchymal stem cell osteogenesis in vitro, and cell deployment in vitro and in vivo, can be controlled by modifying the hydrogel's elastic modulus or its chemistry.
Journal ArticleDOI
Substrate Stress-Relaxation Regulates Scaffold Remodeling and Bone Formation In Vivo.
Max Darnell,Max Darnell,Simon Young,Simon Young,Luo Gu,Luo Gu,Nisarg J. Shah,Nisarg J. Shah,Evi Lippens,James C. Weaver,Georg N. Duda,Georg N. Duda,David J. Mooney,David J. Mooney +13 more
TL;DR: It is suggested that substrate stress relaxation can mediate scaffold remodeling and thus tissue formation, giving tissue engineers a new parameter for optimizing bone regeneration.
Journal ArticleDOI
Gelatin-Based Microcarriers as Embryonic Stem Cell Delivery System in Bone Tissue Engineering: An in-Vitro Study
TL;DR: Mouse embryonic stem cells cultured on commercially available biodegradable macroporous microcarriers retained their pluripotency for up to 14 days when cultured in medium supplemented with leukemia inhibitory factor, and viability of the cells was optimal when gelatin was omitted and when using triacetin instead of HEMA.