F
F. De Luca
Researcher at University of Siena
Publications - 2
Citations - 179
F. De Luca is an academic researcher from University of Siena. The author has contributed to research in topics: Pseudomonas aeruginosa & Lead compound. The author has an hindex of 2, co-authored 2 publications receiving 98 citations.
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Journal ArticleDOI
Discovery of Taniborbactam (VNRX-5133): A Broad-Spectrum Serine- And Metallo-β-lactamase Inhibitor for Carbapenem-Resistant Bacterial Infections
Bin Liu,Robert E. Lee Trout,G.-H. Chu,Mcgarry Daniel G,Randy W. Jackson,Jodie Hamrick,Denis M. Daigle,Susan M Cusick,Cecilia Pozzi,F. De Luca,M. Benvenuti,Stefano Mangani,Jean Denis Docquier,William J. Weiss,Daniel C. Pevear,Luigi Xerri,Christopher J. Burns +16 more
TL;DR: Taniborbactam is the first pan-spectrum β-lactamase inhibitor to enter clinical development and restored the activity of β- lactam antibiotics against carbapenem-resistant Pseudomonas aeruginosa and carbapanem- resistant Enterobacteriaceae.
Journal ArticleDOI
Identification, synthesis and biological activity of alkyl-guanidine oligomers as potent antibacterial agents
Claudio Zamperini,Giorgio Maccari,Davide Deodato,Carolina Pasero,Ilaria D'Agostino,Francesco Orofino,F. De Luca,Elena Dreassi,Jean Denis Docquier,Maurizio Botta,Maurizio Botta +10 more
TL;DR: A batch of a promising candidate for optimization studies turned out to be a mixture containing two unknown species with a better biological activity than the pure compound, and this serendipitous discovery led to investigate the chemical nature of the unknown components of the mixture.