D
Davide Deodato
Researcher at New York University Abu Dhabi
Publications - 26
Citations - 412
Davide Deodato is an academic researcher from New York University Abu Dhabi. The author has contributed to research in topics: Chemistry & Antibacterial activity. The author has an hindex of 11, co-authored 23 publications receiving 292 citations. Previous affiliations of Davide Deodato include University of Siena.
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Journal ArticleDOI
4,6-Diphenylpyridines as Promising Novel Anti-Influenza Agents Targeting the PA-PB1 Protein-Protein Interaction: Structure-Activity Relationships Exploration with the Aid of Molecular Modeling.
Iuni M. L. Trist,Giulio Nannetti,Cristina Tintori,Anna Lucia Fallacara,Davide Deodato,Beatrice Mercorelli,Giorgio Palù,Maikel Wijtmans,Tzveta Gospodova,Ewald Edink,Mark H.P. Verheij,Iwan J. P. de Esch,Lilia Viteva,Arianna Loregian,Maurizio Botta,Maurizio Botta +15 more
TL;DR: Starting from the previously identified 3-cyano-4,6-diphenyl-pyridines, noncytotoxic compounds with both the ability of disrupting the PA-PB1 interaction and antiviral activity were identified and their mechanism of target binding was clarified with molecular modeling simulations.
Journal ArticleDOI
Photochemical Activation of Tertiary Amines for Applications in Studying Cell Physiology.
Naeem Asad,Davide Deodato,Xin Lan,Magnus B. Widegren,David Lee Phillips,Lili Du,Timothy M. Dore,Timothy M. Dore +7 more
TL;DR: Time-resolved spectroscopic studies revealed that photorelease of the tertiary amines was extremely fast, occurring from a singlet excited state of CyHQ on the 70 ps time scale.
Journal ArticleDOI
Discovery and synthesis of novel benzofurazan derivatives as inhibitors of influenza A virus
Ulrich Kessler,Daniele Castagnolo,Mafalda Pagano,Davide Deodato,Martina Bernardini,Beatrice Pilger,Charlene Ranadheera,Maurizio Botta,Maurizio Botta +8 more
TL;DR: A small family of structurally related molecules has been synthesized and biologically evaluated with most of the compounds showing micromolar potency of inhibition against viral replication.
Journal ArticleDOI
Alkyl-guanidine Compounds as Potent Broad-Spectrum Antibacterial Agents: Chemical Library Extension and Biological Characterization.
Carolina Pasero,Ilaria D'Agostino,Filomena De Luca,Claudio Zamperini,Davide Deodato,Giuseppina I. Truglio,Filomena Sannio,Rosita Del Prete,Teresa Ferraro,Daniela Visaggio,Arianna Mancini,Mario B. Guglielmi,Paolo Visca,Jean Denis Docquier,Maurizio Botta,Maurizio Botta +15 more
TL;DR: An alkyl-guanidine derivative, characterized by a symmetrical dimeric structure, is reported as a good candidate for further developments, with a high antibacterial activity against both Gram-positive and Gram-negative strains.
Journal ArticleDOI
The Fight against the Influenza A Virus H1N1: Synthesis, Molecular Modeling, and Biological Evaluation of Benzofurazan Derivatives as Viral RNA Polymerase Inhibitors
Mafalda Pagano,Daniele Castagnolo,Martina Bernardini,Anna Lucia Fallacara,Anna Lucia Fallacara,Ilaria Laurenzana,Davide Deodato,Ulrich Kessler,Beatrice Pilger,Lilli Stergiou,Stephan Strunze,Cristina Tintori,Maurizio Botta,Maurizio Botta +13 more
TL;DR: A large library of benzofurazan compounds synthesized and assayed against influenza virus A/WSN/33 (H1N1) found to act by inhibiting the viral RNA polymerase complex through disruption of the complex formed between subunits PA and PB1.