Ilaria D'Agostino

TL;DR: An alkyl-guanidine derivative, characterized by a symmetrical dimeric structure, is reported as a good candidate for further developments, with a high antibacterial activity against both Gram-positive and Gram-negative strains.

TL;DR: A batch of a promising candidate for optimization studies turned out to be a mixture containing two unknown species with a better biological activity than the pure compound, and this serendipitous discovery led to investigate the chemical nature of the unknown components of the mixture.

TL;DR: Rational design of hybrid compounds starting from a 3-cyano-4,6-diphenylpyridine scaffold recently identified as disruptor of PA-PB1 interactions are reported, that do not show appreciable toxicity.

TL;DR: The research highlights the low in vivo toxicity profile of BM1, its affinity for the renal system in rats and its good absorption, distribution, metabolism, and excretion (ADME) features, which make BM1 and its derivatives a novel promising antifungal class.

TL;DR: An overview of the most interesting RdRp inhibitors that have appeared in the literature since 2000 is presented, and a selection of inhibitors endowed with different scaffolds are described, along with the main features responsible for their activity.